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science

Single-cell transcriptomics identifies the differentiation trajectory from inflammatory monocytes to pro-resolving macrophages in a mouse skin allergy model.

Kensuke Miyake, Junya Ito, Kazufusa Takahashi, Jun Nakabayashi, Frank Brombacher, Shigeyuki Shichino, Soichiro Yoshikawa, Sachiko Miyake, Hajime Karasuyama

Nature communications
Feb 23, 2024
10.1038/s41467-024-46148-4
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Abstract

Both monocytes and macrophages are heterogeneous populations. It was traditionally understood that Ly6Chi classical (inflammatory) monocytes differentiate into pro-inflammatory Ly6Chi macrophages. Accumulating evidence has suggested that Ly6Chi classical monocytes can also differentiate into Ly6Clo pro-resolving macrophages under certain conditions, while their differentiation trajectory remains to be fully elucidated. The present study with scRNA-seq and flow cytometric analyses reveals that Ly6ChiPD-L2lo classical monocytes recruited to the allergic skin lesion sequentially differentiate into Ly6CloPD-L2hi pro-resolving macrophages, via intermediate Ly6ChiPD-L2hi macrophages but not Ly6Clo non-classical monocytes, in an IL-4 receptor-dependent manner. Along the differentiation, classical monocyte-derived macrophages display anti-inflammatory signatures followed by metabolic rewiring concordant with their ability to phagocytose apoptotic neutrophils and allergens, therefore contributing to the resolution of inflammation. The failure in the generation of these pro-resolving macrophages drives the IL-1α-mediated cycle of inflammation with abscess-like accumulation of necrotic neutrophils. Thus, we clarify the stepwise differentiation trajectory from Ly6Chi classical monocytes toward Ly6Clo pro-resolving macrophages that restrain neutrophilic aggravation of skin allergic inflammation.

radiology

Detection Rate of PSMA PET Using Different Ligands in Men with Biochemical Recurrent Prostate Cancer Following Radical Treatment: A Systematic Review and Meta analysis of Prospective Studies

Academic Radiology
Feb 24, 2024
Article
Abstract

Academic Radiology, Volume 31, Issue 2, 2024 Feb, Pages 544 563 | Wu, Qiushuo, B Eng; Bates, Anthony; Guntur, Prasad;...
Background Despite the acknowledged diagnostic detection rate of prostate specific membrane antigen (PSMA) positron emission tomography (PET) imaging in prostate cancer, little is known about the quality of evidence, particularly focusing on prospe...

psychology

Exploring the Landscape of Cognitive Load in Creative Thinking: a Systematic Literature Review

Educational Psychology Review
Feb 24, 2024
10.1007/s10648-024-09866-1
Article Institutional access
Abstract

Creative thinking, recognized as a fundamental life skill, is a complex process influenced by cognitive load. While literature has addressed the integration of cognitive load theory into creative thinking research, a comprehensive synthesis is lacking. To address this gap, we conducted a systematic review and deductive thematic analysis, drawing from 33 eligible articles sourced from Web of Science (WoS), the Educational Resources Information Center (ERIC), and Scopus electronic databases. Thematic analysis identified diverse roles of cognitive load within creativity studies, including mediator, moderator, independent variable, dependent variable, and as a component of the theoretical framework. Management strategies for cognitive load in creativity research involve the use of external resources, environmental interventions, and self regulation. Methodological considerations regarding internal and external validity are also discussed. This review offers implications for researchers and practitioners, informing future research directions and contributing to the effective management of cognitive load in creative thinking practices.

Abstract No. 566 Unlocking Multiomics: Radiomics Feature Analysis for Early Recurrence Prediction Following Ablative Interventions in Early and Very Early Stage Hepatocellular Carcinoma: A Systematic Review and Meta Analysis of 1786 Patients

Journal of Vascular and Interventional Radiology
Feb 24, 2024
Article
Abstract

Journal of Vascular and Interventional Radiology, Volume 35, Issue 3, Supplement, 2024 Mar, Pages S208 S208 | Mirza Aghazadeh Attari, M.; Srinivas, T.; Kim, A.;...Purpose To assess the prognostic value of radiomics features extracted from preprocedural imaging in predicting early recurrence and tumoral progression (defined as recurrence within 2 years) after ablative therapy. Materials and
Method A systema...

oncology

Clinically high risk lobular versus ductal breast cancer: A long term outcome propensity score matched analysis

European Journal of Surgical Oncology
Feb 24, 2024
Article
Abstract

European Journal of Surgical Oncology, Volume 50, Issue 2, 2024 Feb, Article 107530 | Magnoni, Francesca; Corso, Giovanni; Maisonneuve, Patrick;...
Background : The recent MonarchE trial approval of abemaciclib for adjuvant treatment of hormone receptor positive, Her2 negative, node positive breast cancer (BC) has recently reshaped treatment algorithms for this specific subset of disease. Howe...

oncology

Tumour guided cell free tumour DNA analysis in peritoneal fluids of gastric cancer patients can detect occult peritoneal metastases

European Journal of Surgical Oncology
Feb 24, 2024
Article
Abstract

European Journal of Surgical Oncology, Volume 50, Issue 2, 2024 Feb, Article 107409 | Van Der Sluis, Karen; van Sandick, Johanna; Vollebergh, Marieke;...
Background : With current diagnostic tools, adequate detection of limited peritoneal dissemination (PD) in gastric cancer (GC) patients is a challenge. In this study, the feasibility of tumour guided cell free DNA detection in peritoneal fluid of G...

neurology

Cognitive dysfunction in de novo Parkinson disease: Remitting vs. progressive cognitive impairment

Parkinsonism and Related Disorders
Feb 24, 2024
Article
Abstract

Parkinsonism and Related Disorders, Volume 120, 2024 Mar, Article 105984 | Kawabata, Kazuya; Djamshidian, Atbin; Bagarinao, Epifanio;...
Introduction Parkinson's disease (PD) exhibits divergent cognitive trajectories; however, the factors contributing to these variations remain elusive. This study aimed to examine the clinical features of patients with different long term co...

surgery

Early recurrence of hepatocellular carcinoma in patients after ablation and resection: A propensity score analysis

American Journal of Surgery
Feb 24, 2024
Article
Abstract

American Journal of Surgery, The, Volume 228, 2024 Feb, Pages 94 101 | Wu, Zongfeng; Zeng, Yi; Yuan, Yichuan;...
Background Early recurrence (ER, recurrence within 2 years) is common in hepatocellular carcinoma (HCC) patients after ablation and resection. We aimed to compare ER and assess the associated risk factors.
Method We collected data from pati...

oncology

Study design of prebiotic intervention in metastatic colorectal cancer patients treated with 5 FU based chemotherapy: a clinical intervention study.

European Journal of Surgical Oncology
Feb 24, 2024
Article
Abstract

European Journal of Surgical Oncology, Volume 50, Issue 2, 2024 Feb, Article 107647 | Hillege, Lars; Ziemons, Janine; Aarnoutse, Romy;...
Background : For metastatic and/or unresectable CRC, the standard systemic treatment is often based on fluoropyrimidines, such as 5 FU. 5 FU has two significant drawbacks associated with them; (1) only a limited proportion of patients respond to tr...

Abstract No. 79 A Single Center Retrospective Analysis of Microwave Ablation for Primary Lung Cancer

Journal of Vascular and Interventional Radiology
Feb 24, 2024
Article
Abstract

Journal of Vascular and Interventional Radiology, Volume 35, Issue 3, Supplement, 2024 Mar, Pages S36 S36 | McNamara, S.; Uppal, S.; Faintuch, S.Purpose Microwave ablation (MWA) is a thermal technique often used to treat tumors in the liver, kidney, bone, and adrenal gland by inducing tissue necrosis. In lung, however, there is scarce evidence to support its use, particularly for primary l...

Abstract No. 105 Expedited vs Standard Radial Band Deflation Protocol: A Randomized Comparative Analysis of Safety and Efficacy in Radial Artery Access Procedures

Journal of Vascular and Interventional Radiology
Feb 24, 2024
Article
Abstract

Journal of Vascular and Interventional Radiology, Volume 35, Issue 3, Supplement, 2024 Mar, Pages S47 S47 | Nicodemus, A.; Brady, C.; Guimaraes, M.;...Purpose To compare the safety and efficacy of an expedited protocol with the standard protocol for deflation of the TR Band (Terumo) for radial artery access hemostasis. Materials and
Method 30 patients undergoing intra arterial therapy (radioemb...

Abstract No. 600 Safety and Feasibility of the Novel RevCore Thrombectomy Catheter for Venous In Stent Thrombosis: The First Retrospective Analysis

Journal of Vascular and Interventional Radiology
Feb 24, 2024
Article
Abstract

Journal of Vascular and Interventional Radiology, Volume 35, Issue 3, Supplement, 2024 Mar, Pages S221 S222 | Shaikh, A.; Abramowitz, S.Purpose Venous stenting is commonly used to restore outflow and relieve the symptoms of chronic venous insufficiency. When these stents thrombose, limited treatment options exist, often providing only palliative care. Recently, the RevCore Thrombe...

Self perceived concerns regarding sleep quality and its association with anxiety and depressive factors in patients with Hereditary Endocrine Neoplasia type 1: a cross sectional study

Sleep Medicine
Feb 24, 2024
Article

Assessing subjective sleep quality using the Pittsburgh Sleep Quality Index among homeless individuals in São Paulo, Brazil

Sleep Medicine
Feb 24, 2024
Article
Abstract

Sleep Medicine, Volume 115, Supplement 1, 2024 Feb, Pages 85 85 | Benavides Gelvez, R.; Rosa, A.; Hipolide, D.;...
Introduction : Sleep quality is essential for overall well being, and sleep loss is associated with a range of physical and mental health consequences. This study sought to assess the subjective sleep quality of individuals experiencing homelessnes...

medicine

Locoregional Anesthesia`s Association With Reduced Intensive Care Unit Stay After Elective Endovascular Aneurysm Repair: Impact of Temporal Changes in Practice Patterns

Journal of Surgical Research
Feb 24, 2024
Article
Abstract

Journal of Surgical Research, Volume 295, 2024 Mar, Pages 827 836 | Zottola, Zachary R., BS; Lehane, Daniel J., BA; Geiger, Josh T., MD;...
Background Elective endovascular aneurysm repair (EVAR) can be performed via local anesthetics and/or regional (epidural or spinal) anesthesia (locoregional ), versus general anesthesia (GA), conferring reduced intensive care unit (ICU)...

Abstract No. 597 Efficacy and Outcomes of Inferior Vena Cava Filters in High Risk Orthopedic Surgery Patients

Journal of Vascular and Interventional Radiology
Feb 24, 2024
Article
Abstract

Journal of Vascular and Interventional Radiology, Volume 35, Issue 3, Supplement, 2024 Mar, Pages S220 S221 | Koso, M.; Yoder, M.; Makary, M.Purpose This study evaluated the outcomes of orthopedic surgery patients who were protected against pulmonary embolism (PE) with inferior vena cava (IVC) filters. Materials and
Method This institutional review board–approved, single center retros...

oncology

Active surveillance of diffuse type tenosynovial giant cell tumors: A retrospective, multicenter cohort study

European Journal of Surgical Oncology
Feb 24, 2024
Article
Abstract

European Journal of Surgical Oncology, Volume 50, Issue 2, 2024 Feb, Article 107953 | Spierenburg, Geert; Staals, Eric L.; Palmerini, Emanuela;...
Background Diffuse type tenosynovial giant cell tumor (D TGCT) is a mono articular, soft tissue tumor. Although it can behave locally aggressively, D TGCT is a non malignant disease. This is the first study describing the natural course of ...

orthopedics

A Superolateral Cam Lesion Location Increases Odds of Total Hip Arthroplasty 5 Years After Hip Arthroscopy

Arthroscopy: The Journal of Arthroscopic and Related Surgery
Feb 24, 2024
Article
medicine

Association between high or low quality carbohydrate with depressive symptoms and socioeconomic dietary factors model based on XGboost algorithm: From NHANES 2007–2018

Journal of Affective Disorders
Feb 24, 2024
Article
Abstract

Journal of Affective Disorders, Volume 351, 2024 Apr 15, Pages 507 517 | Dang, Xiangji; Yang, Ruifeng; Jing, Qi;...
Background Depressive symptoms are a serious public mental health problem, and dietary intake is often considered to be associated with depressive symptoms. However, the relationship between the quality of dietary carbohydrates and depressi...

psychiatry

The combination of oxytocin and mindfulness based group therapy for empathy and negative symptoms in schizophrenia spectrum disorders – A double blinded, randomized, placebo controlled pilot study

Journal of Psychiatric Research
Feb 24, 2024
Article
Abstract

Journal of Psychiatric Research, Volume 171, 2024 Mar, Pages 222 229 | Zierhut, Marco; Bergmann, Niklas; Hahne, Inge;...
Treatment options for social cognition and negative symptoms in schizophrenia spectrum disorders (SSD) remain limited. Oxytocin could be a promising augmentation approach, but the social context influences the effect in humans. This pilot ...