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chemistry

Yorihisa Hoshino, Shuhei Miyazawa, Hiroshi Nakata, Hironori Etoh, Mitsuko Furitsu, Shinya Abe

1
Jan 1, 1997
Journal of Labelled Compounds and Radiopharmaceuticals
DOI :
10.1002/(sici)1099-1344(199702)39:2<109::aid-jlcr952>3.0.co;2-g
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(S)-N-(endo-8-Methyl-8-azabicyclo[3.2.1]oct-3α-yl)-4-amino-5-chloro-2-(1-methyl-2-butynyloxy)[carbonyl-14C]benzamide monohydrochloride (14C-E3620, 1 1), which was required for a study of the pharmacokinetic profile of E3620, is not only a potent antagonist of 5-HT3 receptors but also a potent agonist of 5-HT4 receptors. It was synthesized using (S)-5-chloro-4-(2,5-dimethylpyrrol-1-yl)-2-(1-methyl-2-butynyloxy)[carboxy-14C]benzoic acid (8) as the labelled starting material. © 1997 John Wiley & Sons, Ltd. The product was produced at high radiochemical purity with a specific activity of 2.02GBq / mmol.

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