Cheng Han Ng, Jieling Xiao, Wen Hui Lim, Yip Han Chin, Jie Ning Yong, Darren Jun Hao Tan, Phoebe Tay, Nicholas Syn, Roger Foo, Mark Chan, Nicholas Chew, Eunice XX Tan, Daniel Q. Huang, Yock Young Dan, Nobuharu Tamaki, Mohammad Shadab Siddiqui, Arun J. Sanyal, Rohit Loomba, Mazen Noureddin, Mark D. Muthiah

Jan 6, 2022
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Background and
Aims The evaluation of the natural history of non‐alcoholic steatohepatitis (NASH) has been limited. Currently, liver biopsy remains the gold standard in the assessment of NASH. Placebo‐controlled trials represent a controlled environment with paired biopsies for the evaluation of NASH. This meta‐analysis thus seeks to quantify the change severity of NASH over time, with patients on placebo arms from randomised controlled trials (RCT) to examine the natural history of NASH.
Method A search was conducted to include NASH RCTs with placebo treatment arms. Primary outcomes were (i) the resolution of NASH without worsening of fibrosis, (ii) 2‐point reduction in NAFLD activity score (NAS) without worsening of fibrosis and (iii) at least 1‐point reduction in fibrosis. Generalized linear mix model was used to estimate pooled proportion and mean differences.
Result This meta‐analysis of 43 RCTs included 2,649 placebo‐treated patients. The pooled estimate of NASH resolution and 2‐point NAS reduction without worsening of fibrosis was 11.65% (95% CI: 7.98 ‐ 16.71) and 21.11% (95% CI: 17.24 ‐ 25.57). The rate of ≥1 stage reduction and progression of fibrosis was and 18.82% (95% CI: 15.65 ‐ 22.47) and 22.74% (CI: 19.63 to 26.17) respectively. Older age and African‐American ethnicity was associated with lower NASH resolution rate in placebo‐treated patients.
Conclusion Despite the absence of any pharmacological interventions, a significant proportion of patients in the placebo arm demonstrated improvements in liver histology, highlighting the possibility that NASH is a disease that can not only progress but regress spontaneously over time. Additionally, histologic response in placebo‐treated patients is helpful in future design of Phase 2B and Phase 3 trials.

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