David Zada, Yaniv Sela, Noa Matosevich, Adir Monsonego, Tali Lerer-Goldshtein, Yuval Nir, Lior Appelbaum

8
Nov 18, 2021
Molecular Cell
DOI :
10.1016/j.molcel.2021.10.026
Article
show_chart

The cellular processes that benefit from sleep and the mechanisms driving sleep regulation remain unclear. Zada et al. report that buildup of DNA damage in neurons during wakefulness increases sleep pressure. Parp1 senses DNA damage and promotes sleep, which facilitates efficient DNA repair and reduction of the cellular homeostatic pressure.

Twitter
Please Log In to leave a comment.