Divakar S Mithal, Navdeep S Chandel

13
Oct 5, 2021
Cell metabolism
DOI :
10.1016/j.cmet.2021.09.006
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Leigh syndrome, a mitochondrial disease, can be modeled in mice with a deficiency in mitochondrial complex I that results in a decreased NAD+/NADH ratio. In this issue of Cell Metabolism, Liu et al. (2021) identify glycerol-3-phosphate (Gro3P) biosynthesis as a method for regenerating cytosolic NAD+ to ameliorate pathology in this mitochondrial disease model.

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