Ensuring international transport corridors’ safety is essential for countries along the routes. For the sustainable development of international transport channels, this paper discusses how to evaluate the operational risks and how to alleviate the adverse effects caused by emergencies. First, an indicator system of international transport corridors’ operational risks was constructed, which consists of 30 indicators from five dimensions of politics, economy, society, safety, and technology. Secondly, a comprehensive scoring approach combined with a network analysis method was applied to examine the effects caused by operational hazards. On this basis, the quantitative method and rigorous statistical analysis were used to evaluate the China Pakistan Iran Turkey International Transport Corridor in the south line of the Silk Road Economic Belt, whose operational risks from 2010 to 2019 were analyzed. Finally, the operational risk index was discussed in detail. Result demonstrate the following. (1) During the China Pakistan Iran Turkey International Transport Corridor, the Pakistan section has the highest operational risk index, and the next culprit is Turkey, followed by Iran. The Chinese section has the lowest operational risk index. (2) Pakistan has been trapped in severe political risks and security risks in recent years. Turkey suffers from severe security risks due to the Kurdish problem. Iran ranks first in terms of economic risk and social risk. Special attention should be paid to the natural risks for China. (3) Pakistan’s operational risks will exhibit consistently high in the future, while China appears downwards in long term trend. The operational risk index in Iran is on the rise. Turkey shows a flattening of and then a slight decline in the foreseeable future.