Danrong Shi, Tianhao Weng, Jie Wu, Chunyan Dai, Rui Luo, Keda Chen, Miaojin Zhu, Xiangyun Lu, Linfang Cheng, Qiuqiang Chen, Fumin Liu, Zhigang Wu, Haibo Wu, Changzhong Jin, Miao Guo, Zhe Chen, Nanping Wu, Hangping Yao, Min Zheng

Jul 20, 2021
Frontiers in Marine Science
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There is a worldwide pandemic of Severe acute respiratory syndrome coronavirus 2 (SARS CoV 2) infection; yet our understanding remains limited on the characteristic of antibodies, especially for dynamic long term tracking. Sequential serum samples were collected up to 416 days post onset of symptoms (POS) from 102 patients who were hospitalized with coronavirus disease 2019 (COVID 19). Immunoglobulin (Ig)G, IgM, and IgA levels targeting SARS CoV 2 spike 1 receptor binding domain (S1 RBD), spike 2 extracellular domain (S2 ECD), and nucleocapsid protein (N) were quantified as well as neutralizing activity. We were pleasantly surprised to find that the antibody remained detective and effective for more than a year POS. We also found the varied reactions of different antibodies as time passed: N IgA rose most rapidly in the early stage of infection, while S2 IgG was present at a high level in the long time of observation. This study described the long traceable antibody response of the COVID 19 and offered hints about targets to screen for postinfectious immunity and for vaccination development of SARS CoV 2.
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