Beatriz Mena-Montes, David Hernández-Álvarez, Gibrán Pedraza-Vázquez, Rafael Toledo-Pérez, Raúl Librado-Osorio, Jorge Antonio García-Álvarez, Adriana Alarcón-Aguilar, Roberto Lazzarini-Lechuga, Oscar Rosas-Carrasco, Mina Königsberg, Norma Edith López-Diazguerrero, Armando Luna-López

Jul 20, 2021
Oxidative Medicine and Cellular Longevity
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The loss of skeletal muscle mass and strength is known as sarcopenia; it is characterized as a progressive and generalized muscle disorder associated with aging. This deterioration can seriously compromise the elderly’s health and reduce their quality of life. In addition to age, there are other factors that induce muscle mass loss, among which are sedentary lifestyle, chronic diseases, inflammation, and obesity. In recent years, a new clinical condition has been observed in older adults that affects their physical capacities and quality of life, which is known as osteosarcopenic obesity (OSO). Osteoporosis, sarcopenia, and obesity coexist in this condition. Physical exercise and nutritional management are the most widely used interventions for the treatment and prevention of sarcopenia. However, in older adults, physical exercise and protein intake do not have the same outcomes observed in younger people. Here, we used a low intensity exercise routine for a long period of time (LIERLT) in order to delay the OSO appearance related to sedentarism and aging in female Wistar rats. The LIERLT routine consisted of walking at 15 m/min for 30 min, five days a week for 20 months. To evaluate the effects of the LIERLT routine, body composition was determined using DXA scan, additionally, biochemical parameters, inflammatory profile, oxidative protein damage, redox state, and serum concentration of GDF 11 at different ages were evaluated (4, 8, 12, 18, 22, and 24 months). Our results show that the LIERLT routine delays OSO phenotype in old 24 month old rats, in a mechanism involving the decrease in the inflammatory state and oxidative stress. GDF 11 was evaluated as a protein related to muscle repair and regeneration; interestingly, rats that perform the LIERLT increased their GDF 11 levels.
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