Traditional manufacturing businesses lack the standards, skills, processes, and technologies to meet today"s challenges of Industry 4.0 driven by an interconnected world. Enterprise Integration and Interoperability can ensure efficient communication among various services driven by big data. However, the data management challenges affect not only the technical implementation of software solutions but the function of the whole organization. In this paper, we bring together Enterprise Integration and Interoperability, Big Data Processing, and Industry 4.0 in order to identify synergies that have the potential to enable the so called “Fourth Industrial Revolution.” On this basis, we propose an architectural framework for designing and modeling Industry 4.0 solutions for big data driven manufacturing operations. We demonstrate the applicability of the proposed framework through its instantiation to predictive maintenance, a manufacturing function that increasingly concerns manufacturers due to the high costs, safety issues, and complexity of its application.