Yoshiyuki Adachi

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Dectin-1 Is Not Required for the Host Defense toCryptococcus neoformans

Kiwamu Nakamura et 10 al.

Nov 1, 2007 in Microbiology and Immunology


Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression.

Ce Tang et 19 al.

Mar 17, 2023 in Nature communications
Dectin-1 (gene Clec7a), a receptor for β-glucans, plays important roles in the host defense against fungi and immune homeostasis of the intestine. Although this molecule is also suggested to be involved in the regulation of tumorigenesis, the role in intestinal tumor development remains to be elucidated. In this study, we find that azoxymethane-dextran-sodium-sulfate-induced and ApcMin-induced int...


Development of a Highly Sensitive β-Glucan Detection System Using Scanning Single-Molecule Counting Method.

Yoshiyuki Adachi, Naohito Ohno et 6 al.

Jun 1, 2021 in International journal of molecular sciences
To overcome the limitations of the Limulus amebocyte lysate (LAL) assay method for the diagnosis of invasive fungal infection, we applied a reaction system combining recombinant β-glucan binding proteins and a scanning single-molecule counting (SSMC) method. A novel (1→3)-β-D-glucan recognition protein (S-BGRP) and a (1→6)-β-glucanase mutant protein were prepared and tested for the binding of (1→6...

Jerveratrum Type Steroidal Alkaloids Inhibit β 1,6 Glucan Biosynthesis in Fungal Cell Walls

Karen Kubo et 54 al.

Jan 12, 2022 in American Society for Microbiology: Microbiology Spectrum
Microbiology Spectrum, Ahead of Print.


Quantification of Mushroom-Derived Soluble β-1,6-Glucan Using the Function-Modified Recombinant β-1,6-Glucanase.

Daisuke Yamanaka, Naohito Ohno et 3 al.

Jan 1, 2020 in International journal of medicinal mushrooms
Mushroom is one of the major sources of β-glucan used in medical applications and traditional therapies. Thus, structure analysis and quantification of β-glucan content is crucial to evaluate medicinal mushrooms. Most studies concerning mushroom-derived β-glucan have been focused on β-1,3-glucans. However, recent investigations suggest that β-1,6 glucans have important roles for immunomodulating a...


Anti β-Glucan Antibody in Cancer Patients (Preliminary Report)

Masuro Motoi, Naohito Ohno et 5 al.

Jan 1, 2004 in International Journal of Medicinal Mushrooms