Yasuharu Kume

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science

The protective role of conjunctival goblet cell mucin sialylation.

Moe Matsuzawa, Jiro Kitaura et 19 al.

Mar 17, 2023 in Nature communications
Gel-forming mucins secreted by conjunctival goblet cells have been implicated in the clearance of allergens, pathogens, and debris. However, their roles remain incompletely understood. Here we show that human and mouse conjunctival goblet cell mucins have Alcian blue-detectable sialic acids, but not sulfates in the steady state. Interestingly, Balb/c mouse strain lacks this sialylation due to a po...