Xinsheng Zhu

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Safety and effectiveness of neoadjuvant PD 1 inhibitor (toripalimab) plus chemotherapy in stage II–III NSCLC (LungMate 002): an open label, single arm, phase 2 trial

Xinsheng Zhu, et 16 al.

Dec 30, 2022 in BMC Medicine
This trial aimed to analyse the safety, effectiveness and transcriptomic characteristics of neoadjuvant toripalimab plus chemotherapy in II–III non small cell lung cancer (NSCLC).

Bevacizumab-Laden Nanofibers Simulating an Antiangiogenic Niche to Improve the Submuscular Stability of Stem Cell Engineered Cartilage.

Xinsheng Zhu, Nan Song et 7 al.

May 12, 2022 in Small
Bone marrow stem cells (BMSCs) engineered cartilage (BEC) is prone to endochondral ossification in a submuscular environment due to the process of vascular infiltration, which limits its application in repairing tracheal cartilage defects. Bevacizumab, an antitumor drug with pronounced antiangiogenic activity, is successfully laden into a poly(L-lactide-co-caprolactone) system to prepare bevacizum...

Sleeve resection after neoadjuvant chemoimmunotherapy in the treatment of locally advanced non-small cell lung cancer.

Jie Dai, Gening Jiang et 14 al.

Feb 1, 2022 in Translational lung cancer research
We aimed to characterize the outcomes of sleeve resection after neoadjuvant chemoimmunotherapy for the treatment of non-small cell lung cancer (NSCLC), including perioperative and oncologic outcomes, and to identify any impact of operative approach on resultant findings. We identified patients with NSCLC who underwent sleeve resection after ≥2 cycles of neoadjuvant chemoimmunotherapy between May 2...


Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma.

Meng Nie, Zeping Hu et 10 al.

Nov 10, 2021 in Nature communications
Metabolic reprogramming evolves during cancer initiation and progression. However, thorough understanding of metabolic evolution from preneoplasia to lung adenocarcinoma (LUAD) is still limited. Here, we perform large-scale targeted metabolomics on resected lesions and plasma obtained from invasive LUAD and its precursors, and decipher the metabolic trajectories from atypical adenomatous hyperplas...

Biomimetic Trachea Engineering via a Modular Ring Strategy Based on Bone‐Marrow Stem Cells and Atelocollagen for use in Extensive Tracheal Reconstruction

Yong Xu, Yang Yang et 12 al.

Nov 6, 2021 in Advanced Materials
The fabrication of biomimetic tracheas with cartilaginous rings alternately interspersed between vascularized fibrous tissue (CRVFT) architecture has the potential to perfectly recapitulate normal tracheal structure and function. Herein, we describe the development of a customized chondroitin sulfate‐incorporated type II atelocollagen (COL II/CS) scaffold with excellent chondrogenic capacity and ...


The relationship between the pH value of dilute effluent streams and system durability in the separate bed electrodeionization process

Ran Tao, Xuhong Yang et 4 al.

Jan 1, 2020 in Separation and Purification Technology
The successful application of electrodeionization (EDI) for the preparation of ultra-pure water has been encouraging researchers to explore its feasibility in the treatment of heavy metal electroplating wastewaters. Based on the separate bed membrane stack, the relationship between the pH of dilute effluent streams and its long-term operation stability was investigated. The pH, conductivity, elec...

Photocrosslinked natural hydrogel composed of hyaluronic acid and gelatin enhances cartilage regeneration of decellularized trachea matrix.

Yong Xu et 11 al.

Jan 1, 2021 in Materials science & engineering. C, Materials for biological applications
Repair of long segmental trachea defects is always a great challenge in the clinic. The key to solving this problem is to develop an ideal trachea substitute with biological function. Using of a decellularized trachea matrix based on laser micropore technique (LDTM) demonstrated the possibility of preparing ideal trachea substitutes with tubular shape and satisfactory cartilage regeneration for ti...

Studies on the interface of glass fiber-reinforced polypropylene composite

Anna Zheng, Seizo Masuda et 3 al.

Jan 1, 2002 in Composite Interfaces
The interfacial characteristics of glass fiber-reinforced polypropylene (PP) are studied with polarized light microscopy, wide angle X-ray diffraction and single fiber fragmentation methods. Transcrystallites are generated at the interface of KH-550 treated glass fiber-reinforced PP when it is blended with maleic anhydride-grafted PP (MA-PP). MA-PP markedly enhanced the interfacial shear strength ...