Alviss

This trial aimed to analyse the safety, effectiveness and transcriptomic characteristics of neoadjuvant toripalimab plus chemotherapy in II–III non small cell lung cancer (NSCLC).

Bone marrow stem cells (BMSCs) engineered cartilage (BEC) is prone to endochondral ossification in a submuscular environment due to the process of vascular infiltration, which limits its application in repairing tracheal cartilage defects. Bevacizumab, an antitumor drug with pronounced antiangiogenic activity, is successfully laden into a poly(L-lactide-co-caprolactone) system to prepare bevacizum...

We aimed to characterize the outcomes of sleeve resection after neoadjuvant chemoimmunotherapy for the treatment of non-small cell lung cancer (NSCLC), including perioperative and oncologic outcomes, and to identify any impact of operative approach on resultant findings. We identified patients with NSCLC who underwent sleeve resection after ≥2 cycles of neoadjuvant chemoimmunotherapy between May 2...

Metabolic reprogramming evolves during cancer initiation and progression. However, thorough understanding of metabolic evolution from preneoplasia to lung adenocarcinoma (LUAD) is still limited. Here, we perform large-scale targeted metabolomics on resected lesions and plasma obtained from invasive LUAD and its precursors, and decipher the metabolic trajectories from atypical adenomatous hyperplas...

The fabrication of biomimetic tracheas with cartilaginous rings alternately interspersed between vascularized fibrous tissue (CRVFT) architecture has the potential to perfectly recapitulate normal tracheal structure and function. Herein, we describe the development of a customized chondroitin sulfate‐incorporated type II atelocollagen (COL II/CS) scaffold with excellent chondrogenic capacity and ...

The successful application of electrodeionization (EDI) for the preparation of ultra-pure water has been encouraging researchers to explore its feasibility in the treatment of heavy metal electroplating wastewaters. Based on the separate bed membrane stack, the relationship between the pH of dilute effluent streams and its long-term operation stability was investigated. The pH, conductivity, elec...

Repair of long segmental trachea defects is always a great challenge in the clinic. The key to solving this problem is to develop an ideal trachea substitute with biological function. Using of a decellularized trachea matrix based on laser micropore technique (LDTM) demonstrated the possibility of preparing ideal trachea substitutes with tubular shape and satisfactory cartilage regeneration for ti...

The interfacial characteristics of glass fiber-reinforced polypropylene (PP) are studied with polarized light microscopy, wide angle X-ray diffraction and single fiber fragmentation methods. Transcrystallites are generated at the interface of KH-550 treated glass fiber-reinforced PP when it is blended with maleic anhydride-grafted PP (MA-PP). MA-PP markedly enhanced the interfacial shear strength ...