Xiangming Quan

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Microbial and metabolic features in renal transplant recipients with post-transplantation diabetes mellitus.

Jiayang He, Liang Wei et 10 al.

Mar 9, 2023 in International journal of urology
Post-transplantation diabetes mellitus (PTDM) is a common complication in renal transplant recipients (RTRs). Gut microbiome plays important roles in a variety of chronic metabolic diseases, but its association with the occurrence and development of PTDM is still unknown. The present study integrates the analysis of gut microbiome and metabolites to further identify the characteristics of PTDM. A ...


Longitudinal genomic alternations and clonal dynamics analysis of primary malignant melanoma of the esophagus.

Jingjing Li, Qing Ye et 12 al.

Jun 1, 2022 in Neoplasia
Primary malignant melanoma of the esophagus (PMME) is a rare gastrointestinal melanoma with a high rate of recurrence and metastasis. The standard of care for PMME has not been established yet due to a lack of understanding of its clinical and molecular pathogenesis. Thus, we performed genomic profiling on a recurrent PMME case to seek novel opportunities for the management of this rare disease. B...

Next-generation Sequencing Reveals Age-dependent Genetic Underpinnings in Lung adenocarcinoma.

Xiaonan Wu, Hong Shi et 17 al.

Mar 6, 2022 in Journal of Cancer
Background : More than 40% of lung cancer patients are diagnosed at ages over 70. However, the genomic and clinical characteristics among them remain elusive. Here, we performed targeted capture sequence to characterize the mutational spectrum of Chinese lung adenocarcinoma (LUAD) patients across ages. Patients and Method : 2025 LUAD patients were divided into three groups: young (≤50 years old) ...

Serum Procalcitonin Correlates With Renal Function and Immune Components in Early-Stage Renal Transplant Recipients.

Xiangming Quan, Liang Wei et 9 al.

Feb 1, 2021 in Transplantation proceedings
In renal transplantation, monitoring procalcitonin (PCT) in the early post-transplant period can be a promising method for early tracking of infectious complications. However, the correlation between PCT and infection-related factors and immune components and renal function remains unclear. Between November 2017 and December 2018, 62 early-stage renal transplant recipients were selected, and 4 mL ...


Genomic Landscape and Tumor Mutational Burden Determination of Circulating Tumor DNA in Over 5,000 Chinese Patients with Lung Cancer.

Jie Shi et 19 al.

Nov 15, 2021 in Clinical cancer research
Having emerged as a noninvasive and clinically applicable approach for molecular determination of lung cancer, a genomic overview of circulating tumor DNA (ctDNA) of large-scale cohort may be helpful in novel biomarker development and therapeutic innovation. Primary cohort encompasses 5,671 blood samples from 4,892 patients with lung cancer. Pair-wise tissue samples from 579 patients and additiona...