Wen Liu

Publications : 109
Aldex : 100
H-index : 11
Citations : 522

physics

C and Si codoping method for p-type AlN

Honglei Wu, Junyi Huang et 4 al.

Sep 1, 2010 in Journal of Applied Physics

Electromagnetic Proton Beam Instabilities in the Inner Heliosphere: Energy Transfer Rate, Radial Distribution, and Effective Excitation

Wen Liu, L. C. Lee et 5 al.

Jul 27, 2021 in Arxiv
Differential flows among different ion species are often observed in the solar wind, and such ion differential flows can provide the free energy to drive Alfv\'en/ion-cyclotron and fast-magnetosonic/whistler instabilities. Previous works mainly focused on ion beam instability under the parameters representative of the solar wind nearby 1 au. In this paper we further study proton beam instability u...

technology

Facile synthesis of mesoporous zirconia nanocrystals in acid/base free conditions

Guoliang Shi, Jing Liang et 7 al.

Jul 25, 2022 in Materials Science and Technology

Insights into catalytic activation of peroxymonosulfate for carbamazepine degradation by MnO2 nanoparticles in-situ anchored titanate nanotubes: Mechanism, ecotoxicity and DFT study.

Fei Pan, Wen Liu et 5 al.

Jan 15, 2021 in Journal of hazardous materials
Developing efficient pharmaceuticals and personal care products (PPCPs) degradation technologies is of scientifical and practical importance to restrain their discharge into natural water environment. This study fabricated and applied a composite material of amorphous MnO2 nanoparticles in-situ anchored titanate nanotubes (AMnTi) to activate peroxymonosulfate (PMS) for efficient degradation and mi...

biology

Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice.

Wen Liu, Xiaochun Bai et 14 al.

May 31, 2019 in Open biology
Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear. Here, we show that tuberous sclerosis complex 1 (TSC1) in osteocytes promotes sclerostin secretion through inhibition of mechanistic target of rapamycin complex 1 (mTORC1) and downregulation of Sirt1. We generated mice with DMP1-Cre-dire...

medicine

Effect of sulfonamide pollution on the growth of manure management candidate Hermetia illucens.

Qiao Gao, Fen Zhu et 6 al.

May 8, 2019 in PloS one
Antibiotics are commonly used in livestock and poultry farming. Residual antibiotics in manure may lead to antibiotic pollution of soil, surface water, and groundwater through land application and run-off rainfall. The black soldier fly (BSF) Hermetia illucens is a good candidate for manure management. We evaluated the effect of sulfonamide pollution on the growth of H. illucens. Four treatments w...

An enzymatic [4 plus 2] cyclization cascade creates the pentacyclic core of pyrroindomycins.

Zhenhua Tian, Wen Liu et 12 al.

Mar 2, 2015 in Nature chemical biology
The [4+2] cycloaddition remains one of the most intriguing transformations in synthetic and natural products chemistry. In nature, however, there are remarkably few enzymes known to have this activity. We herein report an unprecedented enzymatic [4+2] cyclization cascade that has a central role in the biosynthesis of pyrroindomycins, which are pentacyclic spirotetramate natural products. Beginning...

chemistry

Isolation, Structure Elucidation, and Biosynthesis of a Cysteate-Containing Nonribosomal Peptide in Streptomyces lincolnensis.

Min Wang, Wen Liu et 3 al.

Jul 6, 2018 in The Journal of organic chemistry
The species Streptomyces lincolnensis is known as a producer of lincomycin A, a clinically important lincosamide antibiotic with activity against Gram-positive bacteria. Here, we report that S. lincolnensis produces a new cysteate-containing lactone product, cysteoamide (1), which arises from nonribosomal peptide synthetase-programmed sequential assembly of the monomers phenylacetic acid, valine, ...

Structural Insights into a Flavin-Dependent [4  plus 2] Cyclase that Catalyzes trans-Decalin Formation in Pyrroindomycin Biosynthesis.

Qingfei Zheng, Wen Liu et 8 al.

Jun 21, 2018 in Cell chemical biology
Here, we provide structural insights into PyrE3, a flavin-dependent [4 + 2] cyclase that catalyzes trans-decalin formation in the biosynthesis of pyrroindomycins. PyrE3 shares an architecture/domain organization head-to-tail similarity with the members of the family of para-hydroxybenzoate hydroxylase (pHBH)-fold monooxygenases, and possesses a flavin adenine dinucleotide (FAD)-binding domain, a m...

Discovery of caerulomycin/collismycin-type 2,2'-bipyridine natural products in the genomic era.

Dandan Chen, Wen Liu et 2 al.

Nov 27, 2018 in Journal of industrial microbiology & biotechnology
2,2'-Bipyridine (2,2'-BP) is the unique molecular scaffold of the bioactive natural products represented by caerulomycins (CAEs) and collismycins (COLs). CAEs and COLs are highly similar in the chemical structures in which their 2,2'-BP cores typically contain a di- or tri-substituted ring A and an unmodified ring B. Here, we summarize the CAE and COL-type 2,2'-BP natural products known or hypothe...

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