Tuo Yang

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Sulforaphane promotes white matter plasticity and improves long-term neurological outcomes after ischemic stroke via the Nrf2 pathway.

Qianqian Li, Feng Zhang et 4 al.

Nov 20, 2022 in Free radical biology & medicine
Post-stroke cognitive impairment (PSCI) is a common condition following ischemic stroke. Neuronal loss and white matter injury are among the most common neuropathological characteristics in patients with PSCI. The present study tested our hypothesis that activation of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) reduces neuronal loss, white matter injury, and neurobe...

Fatty acid transporting proteins: Roles in brain development, aging, and stroke.

Wenting Zhang et 7 al.

Apr 21, 2017 in Prostaglandins, leukotrienes, and essential fatty acids
Polyunsaturated fatty acids are required for the brain development and significantly impact aging and stroke. Due to the hydrophobicity of fatty acids, fatty acids transportation related proteins that include fatty acid binding proteins (FABPs), long chain acyl-coA synthase (ACS), fatty acid transportation proteins (FATPs), fatty acid translocase (FAT/CD36) and newly reported major facilitator sup...


Protective effects of sulforaphane in experimental vascular cognitive impairment: Contribution of the Nrf2 pathway.

Leilei Mao, Feng Zhang et 9 al.

Mar 13, 2018 in Journal of cerebral blood flow and metabolism
The major pathophysiological process of vascular cognitive impairment (VCI) is chronic cerebral ischemia, which causes disintegration of the blood-brain barrier (BBB), neuronal death, and white matter injury. This study aims to test whether sulforaphane (Sfn), a natural activator of nuclear factor erythroid 2-related factor 2 (Nrf2), reduces the chronic ischemic injury and cognitive dysfunction af...

The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis.

Stanley C Xie, Leann Tilley et 14 al.

Aug 5, 2019 in Nature microbiology
The activity of the proteasome 20S catalytic core is regulated by protein complexes that bind to one or both ends. The PA28 regulator stimulates 20S proteasome peptidase activity in vitro, but its role in vivo remains unclear. Here, we show that genetic deletion of the PA28 regulator from Plasmodium falciparum (Pf) renders malaria parasites more sensitive to the antimalarial drug dihydroartemisini...

Construction of spider silk protein small‐caliber tissue engineering vascular grafts based on dynamic culture and its performance evaluation

Lulu Sun, Liang Zhao et 9 al.

Sep 21, 2022 in Journal of Biomedical Materials Research Part A
Tissue engineering is an alternative method for preparing small caliber (<6 mm) vascular grafts. Dynamic mechanical conditioning is being researched as a method to improve mechanical properties of tissue engineered blood vessels. This method attempts to induce unique reaction in implanted cells that regenerate the matrix around them, thereby improving the overall mechanical stability of the graft...


Neuroprotection against ischemic stroke requires a specific class of early responder T cells in mice.

Wei Cai, Jun Chen et 20 al.

Aug 1, 2022 in The Journal of clinical investigation
Immunomodulation holds therapeutic promise against brain injuries, but leveraging this approach requires a precise understanding of mechanisms. We report that CD8+CD122+CD49dlo T regulatory-like cells (CD8+ TRLs) are among the earliest lymphocytes to infiltrate mouse brains after ischemic stroke and temper inflammation; they also confer neuroprotection. TRL depletion worsened stroke outcomes, an e...

Population‐based metagenomics analysis reveals altered gut microbiome in sarcopenia: data from the Xiangya Sarcopenia Study

Yilun Wang, Guanghua Lei et 9 al.

Jul 18, 2022 in Journal of Cachexia, Sarcopenia and Muscle
Background Several studies have examined gut microbiota and sarcopenia using 16S ribosomal RNA amplicon sequencing; however, this technique may not be able to identify altered specific species and functional capacities of the microbes. We performed shotgun metagenomic sequencing to compare the gut microbiome composition and function between individuals with and without sarcopenia. Method Par...


Genes, Vol. 13, Pages 1280: Plastid Phylogenomics and Plastomic Diversity of the Extant Lycophytes

Sisi Chen, Yuehong Yan et 6 al.

Jul 19, 2022 in Genes
Genes, Vol. 13, Pages 1280: Plastid Phylogenomics and Plastomic Diversity of the Extant Lycophytes Genes doi: 10.3390/genes13071280 Authors: Sisi Chen Ting Wang Jiangping Shu Qiaoping Xiang Tuo Yang Xianchun Zhang Yuehong Yan Although extant lycophytes represent the most ancient surviving lineage of early vascular plants, their plastomic diversity has long been neglected. The ancient evolutionary ...


Mitochondrial Dysfunction in Parkinson’s Disease: From Mechanistic Insights to Therapy

Xiao-Yan Gao, Xiao-Hong Sun et 3 al.

Jun 20, 2022 in Frontiers in Aging Neuroscience
Parkinson’s disease (PD) is one of the most common neurodegenerative movement disorders worldwide. There are currently no cures or preventative treatments for PD. Emerging evidence indicates that mitochondrial dysfunction is closely associated with pathogenesis of sporadic and familial PD. Because dopaminergic neurons have high energy demand, cells affected by PD exhibit mitochondrial dysfunction ...