Selvam Thavaraj

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Treating the N0 neck in early stage oral cancer: a pause for re-assessment?

Andrew Lyons, Peter Brennan et 8 al.

Aug 20, 2021 in The British journal of oral & maxillofacial surgery
The incidence of metastases following neck dissection in the apparent lymph node negative neck in oral cancer is between 7% and 33%; early resection of cervical metastases may well increase survival. Modern imaging techniques can reduce the yield of previously undiagnosed metastatic nodes in elective neck dissection (END). An audit of 112 consecutive cases was conducted to determine the proportion...


Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma.

Takuya Kato, Erik Sahai et 11 al.

Mar 9, 2023 in eLife
Cancers, such as squamous cell carcinoma, frequently invade as multicellular units. However, these invading units can be organised in a variety of ways, ranging from thin discontinuous strands to thick 'pushing' collectives. Here we employ an integrated experimental and computational approach to identify the factors that determine the mode of collective cancer cell invasion. We find that matrix pr...

Adenoid ameloblastoma harbors beta catenin mutations

Victor Coutinho Bastos et 14 al.

Jul 15, 2022 in Modern Pathology

Centralised Pathology Service for Sentinel Node Biopsy in Oral Cavity Cancer: The Southeast England Consortium Experience.

Helina N Patel et 11 al.

Feb 26, 2022 in Journal of oral pathology & medicine
Sentinel lymph node biopsy is an increasingly recognised option for accurate staging and subsequent management of the clinically negative neck in early-stage oral cavity squamous cell carcinoma. However, the technique is currently underused due to several logistical constraints including increased burden on pathology services. Here we describe the feasibility of an outsourced centralised pathology...


Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma.

Matt Lechner, Ehab Y Hanna et 100 al.

Dec 31, 2021 in European journal of cancer
Olfactory neuroblastoma (ONB) is a rare cancer of the sinonasal region. We provide a comprehensive analysis of this malignancy with molecular and clinical trial data on a subset of our cohort to report on the potential efficacy of somatostatin receptor 2 (SSTR2)-targeting imaging and therapy. We conducted a retrospective analysis of 404 primary, locally recurrent, and metastatic olfactory neurobla...


Candida albicans Enhances the Progression of Oral Squamous Cell Carcinoma In Vitro and In Vivo

Máté Vadovics et 74 al.

Jan 4, 2022 in American Society for Microbiology: mBio
mBio, Ahead of Print.

RNA in situ hybridization for human papillomavirus testing in oropharyngeal squamous cell carcinoma on a routine clinical diagnostic platform

Rhonda Henley‐Smith et 5 al.

Sep 1, 2020 in Journal of Oral Pathology & Medicine
Background The current diagnostic standard for detection of high‐risk human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma is via a two‐stage algorithm, namely p16 immunohistochemistry followed by HPV DNA in situ hybridization in p16 positive cases. This study evaluated the feasibility of automated RNA in situ hybridization on a clinical platform as a single‐step alternative to the...


Murine Model of Concurrent Oral and Vaginal Candida albicans Colonisation

Durdana Rahman et 5 al.

Feb 10, 2012 in Methods in molecular biology
Investigations into the complex interaction between the fungal pathogen Candida albicans and its human host require the use of animals as in vivo models. A major advance is the creation of a low-oestrogen murine model of concurrent oral and vaginal C. albicans colonisation that resembles human candidal carriage at both mucosal sites. Weekly intramuscular (5 μg) and subcutaneous (5 μg) oestrogen ad...

Dermatophytes Activate Skin Keratinocytes via Mitogen-Activated Protein Kinase Signaling and Induce Immune Responses

Rebecca R. Achterman et 7 al.

Feb 10, 2015 in Infect. Immun.
Dermatophytes cause superficial and cutaneous fungal infections in immunocompetent hosts and invasive disease in immunocompromised hosts. However, the host mechanisms that regulate innate immune responses against these fungi are largely unknown. Here, we utilized commercially available epidermal tissues and primary keratinocytes to assess (i) damage induction by anthropophilic, geophilic, and zoop...

British Association of Head and Neck Oncologists (BAHNO) standards 2020

Andrew Schache et 20 al.

Mar 3, 2021 in Journal of Oral Pathology & Medicine