Rubya Pereira Zaccaron

Publications : 15
Aldex : 40
H-index : 4
Citations : 39

Photobiomodulation associated with lipid nanoparticles and hyaluronic acid accelerate the healing of excisional wounds

Rubya Pereira Zaccaron et 12 al.

Jun 16, 2022 in Journal of Biomaterials Applications
Journal of Biomaterials Applications, Ahead of Print. Objective : This article aimed to investigate the effects of the association between photobiomodulation and hyaluronic acid incorporated in lipid nanoparticles in an epithelial lesion model in inflammatory parameters and oxidative stress. Method : Eighty Wistar rats were randomly assigned to the following groups: epithelial lesion group (EL);...

medicine

Effects of the Association between Photobiomodulation and Hyaluronic Acid Linked Gold Nanoparticles in Wound Healing.

Carolini Mendes et 12 al.

Jan 1, 2020 in ACS biomaterials science & engineering
Healing is the process responsible for restoring the integrity of the body`s internal or external structures when they rupture. Photobiomodulation (PBM) stands out as one of the most efficient resources in the treatment of epithelial lesions, as well as hyaluronic acid (HA), which has been emerging as a new molecule for the treatment of dermal and epidermal lesions. The biological application of g...

medicine

Treatment with isolated gold nanoparticles reverses brain damage caused by obesity.

Morgana Prá et 20 al.

Jan 1, 2021 in Materials science & engineering. C, Materials for biological applications
In this study, we performed two experiments. In the first experiment, the objective was to link gold nanoparticles (GNPs) with sodium diclofenac and/or soy lecithin and to determine their concentration in tissues and their toxicity using hepatic and renal analyzes in mice to evaluate their safety as therapeutic agents in the subsequent treatment of obesity. In the second experiment, we evaluated t...

Evaluation of the in vivo acute toxicity of poly(thioether‐ester) and superparamagnetic poly(thioether‐ester) nanoparticles obtained by thiol‐ene miniemulsion polymerization

Paulo Emilio Feuser et 10 al.

Oct 7, 2021 in Journal of Biomedical Materials Research Part B
Poly(thioether‐ester) (PTEe) nanoparticles obtained by thiol‐ene polymerization have received attention of many researchers due to several advantages, including, biocompatibility and biodegradability. The search for new nanomaterials requires toxicity studies to assess potential toxic effects of their administration. Therefore, the aim of this study was to evaluate the in vivo acute toxicity of P...


Omega-3 Fatty Acids Attenuate Brain Alterations in High-Fat Diet-Induced Obesity Model

Aline Haas de Mello et 12 al.

May 4, 2018 in Molecular Neurobiology
This study evaluated the effects of omega-3 on inflammation, oxidative stress, and energy metabolism parameters in the brain of mice subjected to high-fat diet-induced obesity model. Body weight and visceral fat weight were evaluated as well. Male Swiss mice were divided into control (purified low-fat diet) and obese (purified high-fat diet). After 6 weeks, the groups were divided into control + s...

pharmacology

Therapeutic effects of iontophoresis with gold nanoparticles in the repair of traumatic muscle injury

Franciani Rodrigues da Rocha et 11 al.

Aug 3, 2019 in Journal of Drug Targeting
Studies have shown the benefits of gold nanoparticles (GNPs) in muscle and epithelial injury models. In physiotherapy, the use of the microcurrent apparatus is associated with certain drugs (Iontophoresis) to increase the topical penetration and to associate the effects of both therapies. Therefore, the objective of this study was to investigate the effects of iontophoresis along with GNPs in the...

pharmacology

Effects of chronic treatment with gold nanoparticles on inflammatory responses and oxidative stress in Mdx mice

Daniela Pacheco dos Santos Haupenthal et 11 al.

May 3, 2019 in Journal of Drug Targeting
Duchenne muscular dystrophy (DMD) is an X-linked recessive hereditary myopathy characterised by progressive muscle degeneration in male children. As a consequence of DMD, increased inflammation and oxidative stress occur in muscle tissue along with morphological changes. Several studies have reported anti-inflammatory and antioxidant effects of gold nanoparticles (GNP) in muscle injury models. Th...

Intranasal insulin treatment modulates the neurotropic, inflammatory, and oxidant mechanisms in the cortex and hippocampus in a low-grade inflammation model

Kellen Ugioni Simon et 8 al.

Oct 1, 2019 in Peptides
The inflammatory process plays a critical role in the development of neurodegenerative diseases. Insulin is used in preclinical and clinical studies of neurological disorders. Its intranasal (IN) administration directly in the brain allows for its peripheral metabolic effects to be avoided. Swiss male mice were injected with lipopolysaccharide (LPS) (0.1 mg/kg) to induce low-grade inflammation. IN...

Effects Of Treatment With Gold Nanoparticles In A Model Of Acute Pulmonary Inflammation Induced By Lipopolysaccharide

Daniela Santos Haupenthal et 9 al.

Sep 10, 2019 in Journal of Biomedical Materials Research Part A
The bacterial lipopolysaccharide (LPS) is a highly toxic molecule derived from the outer membrane of gram-negative bacteria. LPS endotoxin affects the lungs and is used as a model of acute pulmonary inflammation (IPA) affecting the cellular morphology of the organ. Previously, gold nanoparticles have been shown to demonstrate anti-inflammatory and antioxidative activity in muscle and epithelial in...

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