Alviss

(This summary has been generated by AI. Generate your own summaries: https://www.alviss.ai/alboard/#/editorial) A recombinant chimeric protein based vaccine containing t cell epitopes from amastigote proteins and combined with distinct adjuvants, induces immunogenicity and protection against leishmania infantum infection vaccines. Chimt was associated with the adjuvant Saponin or monophosphoryl li...

The use of nanoparticles as drug delivery systems to simultaneously carry several therapeutic agents is an attractive idea to create new synergic treatments and to develop the next generation of cancer therapies. Therefore, the goal of this study was the simultaneous encapsulation of a hydrophilic drug, sodium diethyldithiocarbamate (DETC), and a hydrophobic drug, 4-nitrochalcone (4NC), in beeswax...

Rice is a food crop prone to contamination by toxigenic fungi. Ozone, as a decontamination strategy in the industry, has attractive advantages over traditional food preservation techniques. A contribution to the understanding of ozone as an antifungal agent in rice storage processes is performed in this study. For this, a mathematical model to predict the ozone spread in rice storage in silos was...

Leishmaniasis is a parasitic disease caused by the protozoan of the Leishmania genus. While no human vaccine is available, drugs such as pentavalent antimonials, pentamidine and amphotericin B are used for treat the patients. However, the high toxicity of these pharmaceutics, the emergence of parasite resistance and/or their high cost have showed to the urgent need of identify new targets to be em...

&NA; Bothropasin is a hemorrhagic snake venom metalloproteinase (SVMP) from Bothrops jararaca venom, the snake responsible for most bites in Southeastern Brazil. SVMPs, such as bothropasin, are involved in the main bothropic envenoming symptoms, which include hemorrhage, inflammation, necrosis and blood coagulation deficiency. B‐cell epitope mapping of SVMPs can lead to the identification of pepti...

Visceral leishmaniasis (VL) is a fatal disease when acute and untreated. The treatment against this disease is long and presents toxicity and/or high costs. Moreover, parasite resistance has been increasing. Therefore, alternative control measures to avoid the spread of disease should be considered. It is accepted that the development of the T helper (Th)1 immune response, based on the production ...