Nguyet T Luu
Publications :
2
Aldex :
10
H-index :
2
Citations :
73
Nguyet T Luu
Publications :
2
Aldex :
10
H-index :
2
Citations :
73
Resolving the fibrotic niche of human liver cirrhosis using single-cell transcriptomics
Prakash Ramachandran et 23 al.
Jan 1, 2019 in bioRxiv
Currently there are no effective antifibrotic therapies for liver cirrhosis, a major killer worldwide. To obtain a cellular resolution of directly-relevant pathogenesis and to inform therapeutic design, we profile the transcriptomes of over 100,000 primary human single cells, yielding molecular definitions for the major non-parenchymal cell types present in healthy and cirrhotic human liver. We un...
Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling.
Julia Ast et 15 al.
Jan 18, 2023 in Nature communications
The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor (GPCR) involved in glucose homeostasis and food intake. GLP1R agonists (GLP1RA) are widely used in the treatment of diabetes and obesity, yet visualizing the endogenous localization, organization and dynamics of a GPCR has so far remained out of reach. In the present study, we generate mice harboring an enzyme sel...