Alviss

Gel-forming mucins secreted by conjunctival goblet cells have been implicated in the clearance of allergens, pathogens, and debris. However, their roles remain incompletely understood. Here we show that human and mouse conjunctival goblet cell mucins have Alcian blue-detectable sialic acids, but not sulfates in the steady state. Interestingly, Balb/c mouse strain lacks this sialylation due to a po...

Macular edema is found in more than half of branch retinal vein occlusion (BRVO) cases, leading to visual loss in most of these cases. Intravitreal injection of anti-vascular endothelial growth factor is currently the standard treatment for macular edema due to BRVO (BRVO-ME). The difference in the effects of aflibercept and ranibizumab on the choroid in BRVO-ME is unknown. Therefore, we analyzed ...

We aimed to clarify the role of particulate allergen exposure to the conjunctiva in the development of allergic conjunctivitis. We administered ragweed pollen suspension, pollen extract, pollen shell, particulate air pollutants, and their combinations to the mouse conjunctiva five days a week without prior sensitization. Clinical signs were scored. Histological changes, cellular infiltrations, mRN...

Ceramide-CD300f binding inhibits mouse Mrgprb2 (human MrgprX2)-mediated mast cell activation, thereby suppressing pseudo-allergic reactions. CD300f could be a therapeutic target against IgE-independent pseudo-allergy as well as IgE-dependent allergy.