Mengchang Yang

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Microbial and metabolic features in renal transplant recipients with post-transplantation diabetes mellitus.

Jiayang He, Liang Wei et 10 al.

Mar 9, 2023 in International journal of urology
Post-transplantation diabetes mellitus (PTDM) is a common complication in renal transplant recipients (RTRs). Gut microbiome plays important roles in a variety of chronic metabolic diseases, but its association with the occurrence and development of PTDM is still unknown. The present study integrates the analysis of gut microbiome and metabolites to further identify the characteristics of PTDM. A ...


Long Non-Coding RNA HOTAIR Regulates the Proliferation, Self-Renewal Capacity, Tumor Formation and Migration of the Cancer Stem-Like Cell (CSC) Subpopulation Enriched from Breast Cancer Cells.

Jia Deng, Bin Liu et 5 al.

Jan 25, 2017 in PloS one
Long non-coding RNAs (lncRNAs) play important roles in the malignant behavior of cancer. HOTAIR, a well-studied lncRNA, contributes to breast cancer development, and overexpression of HOTAIR predicts a poor prognosis. However, the regulatory role of HOTAIR in the cancer stem-like cell (CSC) subpopulation remains largely unknown. Our goal was to determine the regulatory functions of HOTAIR in the p...

Upregulation and activation of p53 by erastin‑induced reactive oxygen species contribute to cytotoxic and cytostatic effects in A549 lung cancer cells.

Chaoli Huang, Rong Jiang et 5 al.

Jul 20, 2018 in Oncology reports
The tumour‑suppressor protein p53 is a key regulator of multiple cellular processes and exerts its tumour‑suppressor function by inducing apoptotic cell death. However, emerging evidence indicates that p53 is also involved in inducing ferroptosis, which is a unique iron‑dependent form of non‑apoptotic cell death triggered by the RAS‑selective lethal small molecule erastin. Previous studies have sh...

Efficacy and safety of HSK3486 vs. propofol for the induction and maintenance of general anaesthesia: A multicentre, single-blind, randomised, parallel-group, phase 3 clinical trial.

Peng Liang, Hefan He et 12 al.

Jan 18, 2023 in European journal of anaesthesiology
HSK3486 (ciprofol) is a 2,6-disubstituted phenol derivative that acts like propofol as an agonist at the gamma-aminobutyric acid-A (GABAA) receptor. To investigate the efficacy and safety of HSK3486 for general anaesthesia induction and maintenance. A single-blinded, randomised, parallel-group, phase 3 trial. Involving 10 study centres, from November 24, 2020 to January 25, 2021. A total of 129 pa...


A case report of ciprofol overdose during anesthesia/analgesia and literature review: clinical presentation, blood pressure, and management

Ai Wei, Jiaojie Zhou et 5 al.

Nov 11, 2022 in Journal of International Medical Research
Journal of International Medical Research, Volume 50, Issue 11, November 2022. Ciprofol is a novel intravenous anesthetic agent and a highly selective gamma aminobutyric acid A receptor agonist, similar to propofol. This is the first report about ciprofol overdose occurring during the maintenance phase of anesthesia for a surgical intervention. The accidental administration of an excessive ciprofo...


Prevention of glycopyrrolate against bradycardia induced by neostigmine: a multicenter, randomized, double-blind, doubledummy, parallel-controlled clinical trial

Yuhua Fan, Xiaoming Deng et 36 al.

Jan 1, 2019 in International Journal of Anesthesiology and Resuscitation
Objective To compare the efficacy and safety of glycopyrrolate versus atropine against bradycardia induced by neostigmine. Method Patients scheduled for elective non-cardiac surgery were central randomly assigned to experimental group(n=123) and control group (n=124). Patients in experimental group were administered with glycopyrrolate at a dose of 0.008 mg/kg and neostigmine 0.04 mg/kg in 1 mi...


A Meta Analysis of 5 Hydroxytryptamine Receptor 1B Polymorphisms With Risk of Major Depressive Disorder and Suicidal Behavior

Pingliang Yang, Yundan Liang et 8 al.

Jul 12, 2021 in Frontiers in Psychiatry
Purpose: Previous association studies have investigated whether genetic polymorphisms in HTR1B influenced individuals" susceptibility to major depressive disorder (MDD), anti depressant response (ADR) and suicidal behavior. However, equivocal evidence was obtained. In this meta analysis, we aimed to examine the association of HTR1B polymorphisms with risk of MDD, ADR and suicidal behavior. Materia...

GenCLOn: An ontology for city logistics

Nilesh Anand, Lori Tavasszy et 3 al.

Nov 1, 2012 in Expert Systems with Applications

Effect of the transversus abdominis plane block on postoperative pain and recovery in patients with hepatic echinococcosis

Wenjie Su et 6 al.

Jul 23, 2018 in Journal of International Medical Research
Objective Hepatic echinococcosis (HE) is a severe parasitic disease that occurs worldwide, and radical surgery is the recommended therapy. This study was performed to investigate the efficacy of using a transversus abdominis plane (TAP) block during surgery on postoperative pain and recovery of patients with HE under the guidelines of an enhanced recovery after surgery (ERAS) protocol. Method F...