Alviss

Post-transplantation diabetes mellitus (PTDM) is a common complication in renal transplant recipients (RTRs). Gut microbiome plays important roles in a variety of chronic metabolic diseases, but its association with the occurrence and development of PTDM is still unknown. The present study integrates the analysis of gut microbiome and metabolites to further identify the characteristics of PTDM. A ...

Long non-coding RNAs (lncRNAs) play important roles in the malignant behavior of cancer. HOTAIR, a well-studied lncRNA, contributes to breast cancer development, and overexpression of HOTAIR predicts a poor prognosis. However, the regulatory role of HOTAIR in the cancer stem-like cell (CSC) subpopulation remains largely unknown. Our goal was to determine the regulatory functions of HOTAIR in the p...

The tumour‑suppressor protein p53 is a key regulator of multiple cellular processes and exerts its tumour‑suppressor function by inducing apoptotic cell death. However, emerging evidence indicates that p53 is also involved in inducing ferroptosis, which is a unique iron‑dependent form of non‑apoptotic cell death triggered by the RAS‑selective lethal small molecule erastin. Previous studies have sh...

HSK3486 (ciprofol) is a 2,6-disubstituted phenol derivative that acts like propofol as an agonist at the gamma-aminobutyric acid-A (GABAA) receptor. To investigate the efficacy and safety of HSK3486 for general anaesthesia induction and maintenance. A single-blinded, randomised, parallel-group, phase 3 trial. Involving 10 study centres, from November 24, 2020 to January 25, 2021. A total of 129 pa...

Journal of International Medical Research, Volume 50, Issue 11, November 2022. Ciprofol is a novel intravenous anesthetic agent and a highly selective gamma aminobutyric acid A receptor agonist, similar to propofol. This is the first report about ciprofol overdose occurring during the maintenance phase of anesthesia for a surgical intervention. The accidental administration of an excessive ciprofo...

Objective To compare the efficacy and safety of glycopyrrolate versus atropine against bradycardia induced by neostigmine. Method Patients scheduled for elective non-cardiac surgery were central randomly assigned to experimental group(n=123) and control group (n=124). Patients in experimental group were administered with glycopyrrolate at a dose of 0.008 mg/kg and neostigmine 0.04 mg/kg in 1 mi...

Purpose: Previous association studies have investigated whether genetic polymorphisms in HTR1B influenced individuals" susceptibility to major depressive disorder (MDD), anti depressant response (ADR) and suicidal behavior. However, equivocal evidence was obtained. In this meta analysis, we aimed to examine the association of HTR1B polymorphisms with risk of MDD, ADR and suicidal behavior. Materia...

Objective Hepatic echinococcosis (HE) is a severe parasitic disease that occurs worldwide, and radical surgery is the recommended therapy. This study was performed to investigate the efficacy of using a transversus abdominis plane (TAP) block during surgery on postoperative pain and recovery of patients with HE under the guidelines of an enhanced recovery after surgery (ERAS) protocol. Method F...