Melda Tozluoglu

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biology

Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma.

Takuya Kato, Erik Sahai et 11 al.

Mar 9, 2023 in eLife
Cancers, such as squamous cell carcinoma, frequently invade as multicellular units. However, these invading units can be organised in a variety of ways, ranging from thin discontinuous strands to thick 'pushing' collectives. Here we employ an integrated experimental and computational approach to identify the factors that determine the mode of collective cancer cell invasion. We find that matrix pr...

chemistry

Neph/Nephrin-like adhesion and tissue level pulling forces regulate cell intercalation during Drosophila retina development

Laura Blackie et 7 al.

Jan 1, 2019 in bioRxiv
Intercalation between neighboring cells contributes to shaping epithelial tissues and is regulated by the contractile actomyosin cytoskeleton. While intercalation typically occurs over minutes, instances of much slower cell intercalation have been reported during organogenesis. This is observed, for example, for the four glial-like cone cells (CC) that intercalate during Drosophila retinal pattern...

biology

EpiGraph: an open-source platform to quantify epithelial organization

Pablo Vicente-Munuera et 9 al.

Jan 1, 2018 in bioRxiv
During development, cells must coordinate their differentiation with their growth and organization to form complex multicellular structures such as tissues and organs. Healthy tissues must maintain these structures during homeostasis. Epithelia are packed ensembles of cells from which the different tissues of the organism will originate during embryogenesis. A large barrier to the analysis of the ...

biology

Tissue mechanics regulate mitotic nuclear dynamics during epithelial development

Natalie J Kirkland, Yanlan Mao et 5 al.

Jan 1, 2019 in bioRxiv
Cell divisions are essential for tissue growth. In pseudostratified epithelia, where nuclei are staggered across the tissue, each nucleus migrates apically before undergoing mitosis. Successful apical nuclear migration is critical to preserve tissue integrity during cell division. Most previous investigations have focused on the local cellular mechanisms controlling nuclear migration. Yet, inter-s...

STRIPAK components determine mode of cancer cell migration and metastasis

Chris D. Madsen, Erik Sahai et 8 al.

Dec 22, 2014 in Nature Cell Biology
The contractile actomyosin cytoskeleton and its connection to the plasma membrane are critical for control of cell shape and migration. We identify three STRIPAK complex components, FAM40A, FAM40B and STRN3, as regulators of the actomyosin cortex. We show that FAM40A negatively regulates the MST3 and MST4 kinases, which promote the co-localization of the contractile actomyosin machinery with the E...

Polarization of Myosin II Refines Tissue Material Properties to Buffer Mechanical Stress

Maria Duda, Yanlan Mao et 10 al.

Jan 1, 2019 in Developmental Cell

A combination of Notch signaling, preferential adhesion and endocytosis induces a slow mode of cell intercalation in the Drosophila retina.

Laura Blackie et 7 al.

May 15, 2021 in Development
Movement of epithelial cells in a tissue occurs through neighbor exchange and drives tissue shape changes. It requires intercellular junction remodeling, a process typically powered by the contractile actomyosin cytoskeleton. This has been investigated mainly in homogeneous epithelia, where intercalation takes minutes. However, in some tissues, intercalation involves different cell types and can t...

Tissue Mechanics Regulate Mitotic Nuclear Dynamics during Epithelial Development.

Natalie J Kirkland, Yanlan Mao et 5 al.

May 14, 2020 in Current biology : CB
Cell divisions are essential for tissue growth. In pseudostratified epithelia, where nuclei are staggered across the tissue, each nucleus migrates apically before undergoing mitosis. Successful apical nuclear migration is critical for planar-orientated cell divisions in densely packed epithelia. Most previous investigations have focused on the local cellular mechanisms controlling nuclear migratio...