Matthew Meyerson

Publications : 220
Aldex : 100
H-index : 91
Citations : 109764

Sporadic hemangioblastomas are characterized by cryptic VHL inactivation

Ganesh M Shankar et 30 al.

Dec 1, 2014 in Acta Neuropathologica Communications
Hemangioblastomas consist of 10-20% neoplastic “stromal” cells within a vascular tumor cell mass of reactive pericytes, endothelium and lymphocytes. Familial cases of central nervous system hemangioblastoma uniformly result from mutations in the Von Hippel-Lindau (VHL) gene. In contrast, inactivation of VHL has been previously observed in only a minority of sporadic hemangioblastomas, suggesting a...

medicine

Sequence-based discovery of Bradyrhizobium enterica in cord colitis syndrome.

Ami S Bhatt et 24 al.

Aug 8, 2013 in The New England journal of medicine
Immunosuppression is associated with a variety of idiopathic clinical syndromes that may have infectious causes. It has been hypothesized that the cord colitis syndrome, a complication of umbilical-cord hematopoietic stem-cell transplantation, is infectious in origin. We performed shotgun DNA sequencing on four archived, paraffin-embedded endoscopic colon-biopsy specimens obtained from two patient...

medicine

Signatures of mutational processes in human cancer.

Ludmil B Alexandrov et 71 al.

Aug 22, 2013 in Nature
All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is limited. The catalogue of somatic mutations from a cancer genome bears the signatures of the mutational processes that have been operative. Here we analysed 4,938,362 mutations from 7,042 cancers and extracted more than 20 distinct mutational signatures. Some are present in...

cancer

An international report on bacterial communities in esophageal squamous cell carcinoma

Jason Nomburg et 36 al.

Jul 15, 2022 in International Journal of Cancer
The incidence of esophageal squamous cell carcinoma (ESCC) is disproportionately high in the eastern corridor of Africa and parts of Asia. Emerging research has identified a potential association between poor oral health and ESCC. One possible link between poor oral health and ESCC involves the alteration of the microbiome. We performed an integrated analysis of four independent sequencing effort...

Telomerase as a therapeutic target in glioblastoma.

Elisa Aquilanti et 4 al.

Dec 1, 2021 in Neuro-oncology
Glioblastoma is the most common primary malignant brain tumor in adults and it continues to have a dismal prognosis. The development of targeted therapeutics has been particularly challenging, in part due to a limited number of oncogenic mutations and significant intra-tumoral heterogeneity. TERT promoter mutations were first discovered in melanoma and later found to be present in up to 80% of gli...

cancer

FGFR2 Extracellular Domain In-Frame Deletions Are Therapeutically Targetable Genomic Alterations That Function as Oncogenic Drivers in Cholangiocarcinoma.

James M Cleary et 40 al.

Apr 29, 2021 in Cancer discovery
We conducted next-generation DNA sequencing on 335 biliary tract cancers and characterized the genomic landscape by anatomic site within the biliary tree. In addition to frequent FGFR2 fusions among patients with intrahepatic cholangiocarcinoma (IHCC), we identified FGFR2 extracellular domain in-frame deletions (EID) in 5 of 178 (2.8%) patients with IHCC, including two patients with FGFR2 p. H167_...

oncology

Functional genomic analysis of CDK4 and CDK6 gene dependency across human cancer cell lines.

Zhouwei Zhang et 3 al.

Apr 8, 2022 in Cancer research
Cyclin-dependent kinase 4 (CDK4) and cyclin-dependent kinase 6 (CDK6) are key cell cycle regulators that are frequently dysregulated in human malignancies. CDK4/6 inhibitors are clinically approved for the treatment of hormone receptor-positive, HER2-negative (HR+/HER2-) breast cancer, but improved specificity and reduced toxicity might expand their use to other indications. Through analysis of pu...

Long-read sequencing reveals complex patterns of wraparound transcription in polyomaviruses.

Jason Nomburg et 9 al.

Apr 1, 2022 in PLoS pathogens
Polyomaviruses (PyV) are ubiquitous pathogens that can cause devastating human diseases. Due to the small size of their genomes, PyV utilize complex patterns of RNA splicing to maximize their coding capacity. Despite the importance of PyV to human disease, their transcriptome architecture is poorly characterized. Here, we compare short- and long-read RNA sequencing data from eight human and non-hu...


science

Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.

Colin W Garvie et 28 al.

Jul 16, 2021 in Nature communications
DNMDP and related compounds, or velcrins, induce complex formation between the phosphodiesterase PDE3A and the SLFN12 protein, leading to a cytotoxic response in cancer cells that express elevated levels of both proteins. The mechanisms by which velcrins induce complex formation, and how the PDE3A-SLFN12 complex causes cancer cell death, are not fully understood. Here, we show that PDE3A and SLFN1...

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