Lorenzo Del Sorbo

Publications : 3
Aldex : 100
H-index : 0
Citations : 0


Thrombopoietin Contributes to Enhanced Platelet Activation in Patients With Unstable Angina

Enrico Lupia et 10 al.

Dec 1, 2006 in Journal of the American College of Cardiology

Airway Closure During Extracorporeal Membrane Oxygenation: The AiCLOSE Study

Hesham Abdelhady, Michael Sklar et 6 al.

Dec 15, 2021 in ClinicalTrials.gov
About 65,000 Canadians develop acute respiratory failure requiring breathing machines (ventilators) to give oxygen to their lungs. Unfortunately, up to 50% of these individuals will not survive their illness. Mechanical ventilation through breathing machines, though potentially lifesaving, may further injure the lungs and the respiratory muscles. In the patients with the most severe and life threa...

Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

Hadi Hatoum, Derek Angus et 135 al.

Dec 11, 2015 in ClinicalTrials.gov
REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia. The purpose of this study is to evaluate the effect of a range of interventions to improve outcome of patients admitted to intensive care with community-acquired pneumonia. In addition, REMAP-CAP provides and adaptive research platform for evaluation of multiple treatment modalities in th...

Ultra-Low Tidal Volume Mechanical Ventilation in ARDS Through ECMO

Daniel Brodie, Eddy Fan et 18 al.

Mar 28, 2021 in ClinicalTrials.gov
Primary Research Question for the Full ULTIMATE Randomized Clinical Trial (RCT): What is the effect of ultra-protective ventilation facilitated by extracorporeal membrane oxygenation (ECMO) versus best current conventional ventilation (CV) on all-cause hospital mortality among patients with early moderate-severe acute respiratory distress syndrome (ARDS)? Secondary Research Questions: Among patien...

HNFO With or Without Helmet NIV for Oxygenation Support in Acute Respiratory Failure Pilot RCT

Bram Rochwerg et 4 al.

Oct 1, 2021 in ClinicalTrials.gov
This Randomized Control Trial will directly compare helmet non-invasive ventilation (NIV) combined with high flow nasal oxygen (HFNO) versus HFNO alone in patients with Acute Hypoxemic Respiratory Failure (AHRF).

Determining the impact of ex-vivo lung perfusion on hospital costs for lung transplantation: A retrospective cohort study.

John Kenneth Peel, Beate Sander et 8 al.

Nov 9, 2022 in The Journal of heart and lung transplantation
Ex-vivo lung perfusion (EVLP) has improved organ utilization for lung transplantation, but it is not yet known whether the benefits of this technology offset its additional costs. We compared the institutional costs of lung transplantation before vs after EVLP was available to identify predictors of costs and determine the health-economic impact of EVLP. We performed a retrospective, before-after,...


Therapeutic advances in COVID-19

Naoka Murakami, David E. Leaf et 8 al.

Oct 17, 2022 in Nature Reviews Nephrology
Over 2 years have passed since the start of the COVID-19 pandemic, which has claimed millions of lives. Unlike the early days of the pandemic, when management decisions were based on extrapolations from in vitro data, case reports and case series, clinicians are now equipped with an armamentarium of therapies based on high-quality evidence. These treatments are spread across seven main therapeutic...

Thrombopoietin participates in platelet activation in COVID-19 patients.

Enrico Lupia et 13 al.

Oct 12, 2022 in EBioMedicine
The pathogenesis of coronavirus disease 2019 (COVID-19) is characterized by enhanced platelet activation and diffuse hemostatic alterations, which may contribute to immunothrombosis/thromboinflammation and subsequent development of target-organ damage. Thrombopoietin (THPO), a growth factor essential to megakariocyte proliferation, is known to prime platelet activation and leukocyte-platelet inter...

The Association Between Extravascular Lung Water and Critical Care Outcomes Following Bilateral Lung Transplantation.

Laveena Munshi, John Granton et 10 al.

Sep 26, 2022 in Transplantation direct
Primary graft dysfunction (PGD) is a form of acute respiratory failure that complicates 30% of bilateral lung transplants. Higher grades of PGD correlate with higher severity of respiratory failure and unfavorable outcomes. Immediate PGD determination posttransplant' however, is not always predictive of PGD over subsequent days or intensive care unit outcomes. We aimed to evaluate whether extravas...


A biomarker assay to risk-stratify patients with symptoms of respiratory tract infection.

Shahid Husain et 32 al.

Sep 14, 2022 in The European respiratory journal
Patients who present to an emergency department with respiratory symptoms are often conservatively triaged in favour of hospitalization. We sought to determine if an inflammatory biomarker panel that identifies the host response better predicts hospitalization in order to improve the precision of clinical decision-making in the emergency department. From April 2020 to March 2021, plasma samples of...

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