Alviss

Regioselective C–H trifluoromethylation of imidazoheterocycles with Langlois` reagent in a recyclable mixed medium of 1-butyl-3-methylimidazoliumtetrafluoroborate ([Bmim]BF4) and water at room temperature has been developed. In the presence of catalytic cupric acetate and 2-methyl-2-(methylperoxy)propane (TBHP), this green strategy tolerates a wide range of functional groups to afford diverse trif...

Graft-derived cell-free DNA (GcfDNA) is a promising biomarker for comprehensive monitoring of allograft injury because it overcomes the limitations of traditional approaches. The aim of this study is to investigate the association between the outliers of GcfDNA at initial time post transplantation and short-term renal graft function. A total of 230 recipients who underwent primary kidney transplan...

Post-transplantation diabetes mellitus (PTDM) is a common complication in renal transplant recipients (RTRs). Gut microbiome plays important roles in a variety of chronic metabolic diseases, but its association with the occurrence and development of PTDM is still unknown. The present study integrates the analysis of gut microbiome and metabolites to further identify the characteristics of PTDM. A ...

Gambogic acid (GA) as an active compound isolated from Gamboge, have been investigated for many years and proved to be a promising natural anticancer agent for clinical treatment. This study aimed to investigate the inhibitory effect of docetaxel (DTX) combined with gambogic acid on bone metastasis of lung cancer. The anti-proliferation effect of the combination of DTX and GA on Lewis lung cancer ...

In recent years, heavy metal pollution in farmlands has become increasingly serious because of human activities such as metal smelting, sewage irrigation, and road traffic in China. A field survey was conducted to investigate characteristics of Cd, As, and Pb in soil and wheat grains and assess the health risk of grain-Cd/As/Pb to humans on the fields scale. The farmland was influenced by smelter ...

Inside Cover: A self‐pumping multichannel dressing is designed and prepared. The hydrophobic electrospun membrane and hydrophilic surface layer of the 3D spacer fabric are combined to form a Janus structure. Furthermore, aerogel transport channels are constructed by attaching them to the spacer yarns. The dressing can quickly absorb and transport liquid, while exhibits excellent vertical and horiz...

Polymers, Vol. 15, Pages 741: Research Progress of Water Treatment Technology Based on Nanofiber Membranes Polymers doi: 10.3390/polym15030741 Authors: Keyu Ji Chengkun Liu Haijun He Xue Mao Liang Wei Hao Wang Mengdi Zhang Yutong Shen Runjun Sun Fenglei Zhou In the field of water purification, membrane separation technology plays a significant role. Electrospinning has emerged as a primary method ...

CRISPR-Cas provides bacteria and archaea with immunity against invading phages and foreign plasmid DNA and has been successfully adapted for gene editing in a variety of species. The class 2 type VI CRISPR-Cas effector Cas13a targets and cleaves RNA, providing protection against RNA phages. Here we report the repurposing of CRISPR-Cas13a to inhibit human immunodeficiency virus type 1 (HIV-1) infec...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines provide essential tools for the control of the COVID-19 pandemic. A number of technologies have been employed to develop SARS-CoV-2 vaccines, including the inactivated SARS-CoV-2 particles, mRNA to express viral spike protein, recombinant spike proteins, and viral vectors. Here, we report the use of the vaccinia virus Tiantan st...

The cyclic GMP-AMP (cGAMP) synthase (cGAS) is a key DNA sensor that initiates STING-dependent signaling to produce type I interferons through synthesizing the secondary messenger 2'3'-cGAMP. In this study, we confirm previous studies showing that cGAS is located both in the cytoplasm and in the nucleus. Nuclear accumulation is observed when leptomycin B is used to block the exportin, CRM1 protein....