Keiko Maeda

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Nutrients, Vol. 15, Pages 1473: Proteomic Analysis Reveals Changes in Tight Junctions in the Small Intestinal Epithelium of Mice Fed a High Fat Diet

Hisanori Muto et 16 al.

Mar 19, 2023 in Nutrients
Nutrients, Vol. 15, Pages 1473: Proteomic Analysis Reveals Changes in Tight Junctions in the Small Intestinal Epithelium of Mice Fed a High Fat Diet Nutrients doi: 10.3390/nu15061473 Authors: Hisanori Muto Takashi Honda Taku Tanaka Shinya Yokoyama Kenta Yamamoto Takanori Ito Norihiro Imai Yoji Ishizu Keiko Maeda Tetsuya Ishikawa Shungo Adachi Chikara Sato Noriko M. Tsuji Masatoshi Ishigami Mitsuhi...


The protective role of conjunctival goblet cell mucin sialylation.

Moe Matsuzawa, Jiro Kitaura et 19 al.

Mar 17, 2023 in Nature communications
Gel-forming mucins secreted by conjunctival goblet cells have been implicated in the clearance of allergens, pathogens, and debris. However, their roles remain incompletely understood. Here we show that human and mouse conjunctival goblet cell mucins have Alcian blue-detectable sialic acids, but not sulfates in the steady state. Interestingly, Balb/c mouse strain lacks this sialylation due to a po...

Reliability and Validity of the Japanese Version of the Basel Assessment of Adherence to Immunosuppressive Medications Scale in Kidney Transplant Recipients.

Akihiro Kosoku, Junji Uchida et 9 al.

Feb 24, 2023 in Transplantation direct
A valid and reliable instrument that can measure adherence is needed to identify nonadherent patients and to improve adherence. However, there is no validated Japanese self-report instrument to evaluate adherence to immunosuppressive medications for transplant patients. The purpose of this study was to determine the reliability and validity of the Japanese version of the Basel Assessment of Adhere...


Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells.

Keiko Maeda et 20 al.

Feb 29, 2016 in Scientific reports
Bone marrow-derived mesenchymal stromal cells (BM-MSCs) in culture are derived from BM stromal cells or skeletal stem cells. Whereas MSCs have been exploited in clinical medicine, the identification of MSC-specific markers has been limited. Here, we report that a cell surface and secreted protein, Meflin, is expressed in cultured MSCs, fibroblasts and pericytes, but not other types of cells includ...


Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction.

Akitoshi Hara et 23 al.

Aug 2, 2019 in Circulation research
Myofibroblasts have roles in tissue repair following damage associated with ischemia, aging, and inflammation and also promote fibrosis and tissue stiffening, causing organ dysfunction. One source of myofibroblasts is mesenchymal stromal/stem cells that exist as resident fibroblasts in multiple tissues. We previously identified meflin (mesenchymal stromal cell- and fibroblast-expressing Linx paral...


Efficacy of 1‐kestose supplementation in patients with mild to moderate ulcerative colitis: A randomised, double‐blind, placebo‐controlled pilot study

Shuji Ikegami et 19 al.

Jan 16, 2023 in Alimentary Pharmacology & Therapeutics
Efficacy of 1 kestose supplementation in patients with mild to moderate ulcerative colitis. Background Ulcerative colitis involves an excessive immune response to intestinal bacteria. Whether administering prebiotic 1 kestose is effective for active ulcerative colitis remains controversial. Aims This randomised, double blind, placebo controlled pilot trial investigated the efficacy of 1 kest...


CO2 enterography in endoscopic retrograde cholangiography using double-balloon endoscopy: randomized clinical trial.

Kentaro Murate et 20 al.

Jan 17, 2023 in Journal of gastroenterology and hepatology
Background and Aim Double balloon endoscopic retrograde cholangiography (DBERC) is a valuable procedure for patients with altered gastrointestinal anatomy. Nonetheless, it is time consuming and burdensome for both patients and endoscopists, partly because route selection in the reconstructed bowel with complicating loop is challenging. Carbon dioxide insufflation enterography is reportedly usef...

Analysis of immunologic comorbidities in ulcerative colitis patients: a tool to prevent exacerbations in ulcerative colitis cases.

Miguel Ricardo Rodríguez Meza et 15 al.

Nov 1, 2022 in Nagoya journal of medical science
There have been previous studies, especially in Western countries and even in some areas in Asia, about extra-intestinal manifestations (EIMs) and its link with the outcome of inflammatory bowel disease (IBD), which includes Crohn's disease (CD), and ulcerative colitis (UC). This link is crucial when discussing a patient's prognosis and important when dealing with UC management. The aim of this st...

The effects of ustekinumab on small intestinal lesions and stenotic lesions.

Hirotaka Wada et 17 al.

Nov 1, 2022 in Nagoya journal of medical science
Crohn's disease patients suffer from symptoms originating from small bowel lesions, including strictures. As many of these patients also have a potential risk of surgery, it is important to consider various therapeutic strategies for small bowel lesions. We retrospectively analyzed the therapeutic effects of ustekinumab, interleukin-12 and -23 blocker, for small intestinal lesions and intestinal s...