Kamen A Tsvetanov

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Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes.

Frank H Hezemans, James B Rowe et 14 al.

May 9, 2022 in PLoS computational biology
Apathy is a debilitating feature of many neuropsychiatric diseases, that is typically described as a reduction of goal-directed behaviour. Despite its prevalence and prognostic importance, the mechanisms underlying apathy remain controversial. Degeneration of the locus coeruleus-noradrenaline system is known to contribute to motivational deficits, including apathy. In healthy people, noradrenaline...


Quality assessment of anatomical MRI images from generative adversarial networks: Human assessment and image quality metrics.

Matthias S Treder et 3 al.

May 15, 2022 in Journal of neuroscience methods
Generative Adversarial Networks (GANs) can synthesize brain images from image or noise input. So far, the gold standard for assessing the quality of the generated images has been human expert ratings. However, due to limitations of human assessment in terms of cost, scalability, and the limited sensitivity of the human eye to more subtle statistical relationships, a more automated approach towards...

In vivo 18F-flortaucipir PET does not accurately support the staging of progressive supranuclear palsy.

Maura Malpetti, James B Rowe et 19 al.

Nov 18, 2021 in Journal of nuclear medicine
Progressive Supranuclear Palsy (PSP) is a neurodegenerative disorder characterised by neuro-glial tau pathology. A new staging system for PSP pathology at post-mortem has been described and validated. We used a data-driven approach to test whether post-mortem pathological staging in PSP can be reproduced in vivo with 18F-flortaucipir PET. Method : N = 42 patients with probable PSP and N = 39 cont...


Trajectory of apathy, cognition and neural correlates in the decades before symptoms in frontotemporal dementia

Maura Malpetti, James B Rowe et 35 al.

Jan 1, 2020 in Alzheimer`s & Dementia
In frontotemporal dementia (FTD), apathy is reported to negatively impact the prognosis and survival of patients. The study of genetic FTD in its pre‐symptomatic period permits the investigation of markers in the early stages of disease progression. Therefore, in pre‐symptomatic gene carriers in the multicentre Genetic FTD Initiative (GENFI), we examined longitudinal apathy changes in association ...


The prognostic role of microglia and tau PET in Alzheimer’s disease

Maura Malpetti, James B Rowe et 14 al.

Jan 1, 2020 in Alzheimer`s & Dementia
Neuroinflammation is part of the pathophysiology of Alzheimer’s disease (AD), in addition to amyloid‐β plaques and tau neurofibrillary tangles. PET markers of microglial activation have indicated inflammation of temporo‐parietal regions, in proportion to disease severity. Here we test the prognostic value of [11C]PK11195 PET on longitudinal clinical decline in AD, alone and in combination with MRI...


Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool

Katie A. Peterson, James B. Rowe et 9 al.

Jul 19, 2021 in Frontiers in Aging Neuroscience
Background : Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) affect speech and language as well as motor functions. Clinical and neuropathological data indicate a close relationship between these two disorders and the non fluent variant of primary progressive aphasia (nfvPPA). We use the recently developed Mini Linguistic State Examination tool (MLSE) to study speech and langu...

Age-related reduction in motor adaptation: brain structural correlates and the role of explicit memory.

Noham Wolpe, James B Rowe et 5 al.

Feb 20, 2020 in Neurobiology of aging
The adaption of movement to changes in the environment varies across life span. Recent evidence has linked motor adaptation and its reduction with age to differences in "explicit" learning processes. We examine differences in brain structure and cognition underlying motor adaptation in a population-based cohort (n = 322, aged 18-89 years) using a visuomotor learning task and structural magnetic re...

Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes.

Maura Malpetti et 39 al.

Dec 14, 2020 in Alzheimer's & dementia
Apathy adversely affects prognosis and survival of patients with frontotemporal dementia (FTD). We test whether apathy develops in presymptomatic genetic FTD, and is associated with cognitive decline and brain atrophy. Presymptomatic carriers of MAPT, GRN or C9orf72 mutations (N = 304), and relatives without mutations (N = 296) underwent clinical assessments and MRI at baseline, and annually for 2...

Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes.

Alexander G Murley, James B Rowe et 12 al.

May 1, 2020 in Brain : a journal of neurology
The syndromes caused by frontotemporal lobar degeneration have highly heterogeneous and overlapping clinical features. There has been great progress in the refinement of clinical diagnostic criteria in the past decade, but we propose that a better understanding of aetiology, pathophysiology and symptomatic treatments can arise from a transdiagnostic approach to clinical phenotype and brain morphom...