Junrui Cheng

Publications : 20
Aldex : 80
H-index : 5
Citations : 91


Carotenoids in orange carrots mitigate non alcoholic fatty liver disease progression

Emilio Balbuena et 3 al.

Sep 26, 2022 in Frontiers in Nutrition
Background Carotenoids are abundant in colored fruits and vegetables. Non alcoholic fatty liver disease (NAFLD) is a global burden and risk factor for end stage hepatic diseases. This study aims to compare the anti NAFLD efficacy between carotenoid rich and carotenoid deficient vegetables. Materials and methodsMale C57BL/6J mice were randomized to one of four experimental diets for 15 weeks (n = 1...


Personalized nutrition: A review of genotype based nutritional supplementation

Feijie Wang, Juntao Kan et 15 al.

Sep 9, 2022 in Frontiers in Nutrition
Nutritional disorders have become a major public health issue, requiring increased targeted approaches. Personalized nutrition adapted to individual needs has garnered dramatic attention as an effective way to improve nutritional balance and maintain health. With the rapidly evolving fields of genomics and nutrigenetics, accumulation of genetic variants has been indicated to alter the effects of n...

Gut microbiota: Linking nutrition and perinatal depression

Jia Song, Xiaobo Liu et 11 al.

Aug 26, 2022 in Frontiers in Cellular and Infection Microbiology
Perinatal depression is a mood disorder that is reported in women during pregnancy (prenatal) and after childbirth (postnatal). The onset of perinatal depression is associated with changes in reproductive hormones, stress hormones and neurosteroids. These chemical compounds can be modulated by the gut microbiota, which may affect maternal mental health during the perinatal period via the gut brain...


Personalized Nutrition Intervention Improves Health Status in Overweight/Obese Chinese Adults: A Randomized Controlled Trial

Juntao Kan, Jun Du et 9 al.

Jun 22, 2022 in Frontiers in Nutrition
Background Overweight and obesity increase the risk of noncommunicable diseases (NCDs). Personalized nutrition (PN) approaches may provide tailored nutritional advice/service by focusing on individual"s unique characteristics to prevent against NCDs. Objective We aimed to compare the effect of PN intervention with the traditional “one size fits all” intervention on health status in overweight/obe...


The Role of β Carotene in Colonic Inflammation and Intestinal Barrier Integrity

Junrui Cheng et 4 al.

Sep 27, 2021 in Frontiers in Nutrition
Background : Carotenoids are naturally occurring pigments accounting for the brilliant colors of fruits and vegetables. They may display antioxidant and anti inflammatory properties in humans besides being precursors to vitamin A. There is a gap of knowledge in examining their role within colonic epithelial cells. We proposed to address this research gap by examining the effects of a major dietary...


The combination of wheat peptides and fucoidan protects against chronic superficial gastritis and alters gut microbiota: a double-blinded, placebo-controlled study.

Juntao Kan, Jun Du et 8 al.

Jun 22, 2019 in European journal of nutrition
Chronic gastritis is observed in almost half world population. Traditional medications against chronic gastritis might produce adverse effects, so alternative nutritional strategies are needed to prevent the aggravation of gastric mucosal damage. The aim of this study is to evaluate the protective effect of the combination of wheat peptides and fucoidan (WPF) on adults diagnosed with chronic super...

Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization

Junrui Cheng et 8 al.

Aug 1, 2017 in Biochimica et Biophysica Acta - Molecular Basis of Disease
Sirtuin 1 (SIRT1) has been reported to protect against nonalcoholic fatty liver disease (NAFLD) development. The mechanism of how SIRT1 deacetylase activity affects NAFLD has not been well investigated. The current investigation addressed the causal effect of systemic SIRT1 activity on NAFLD development and the underlying mechanism involved in both liver and mesenteric adipose tissue (MAT). Both S...


An improved AEA using local search and its application to parameter estimation for homogeneous mercury oxidation

Junrui Cheng, Shaojun Li et 2 al.

Feb 1, 2015 in Chemometrics and Intelligent Laboratory Systems
The Alopex-based evolutionary algorithm (AEA) possesses the basic characteristics of evolutionary algorithms as well as the advantages of the simulated annealing algorithm and gradient descent methods. The AEA is good at exploration but poor at exploitation, which results to some extent in poor convergence. To improve the performance of the basic AEA, we propose a local search algorithm in this p...

Tomato Powder Inhibits Hepatic Steatosis and Inflammation Potentially Through Restoring SIRT1 Activity and Adiponectin Function Independent of Carotenoid Cleavage Enzymes in Mice

Cheng-Chung Li et 10 al.

Dec 20, 2017 in Molecular Nutrition & Food Research
SCOPE Beta-carotene-15,15`-oxygenase (BCO1) and beta-carotene-9`,10`-oxygenase (BCO2) metabolize lycopene to biologically active metabolites, which can ameliorate nonalcoholic fatty liver disease (NAFLD). We investigate the effects of tomato powder (TP containing substantial lycopene (2.3 mg/g)) on NAFLD development and gut microbiome in the absence of both BCO1 and BCO2 in mice. METHOD AND RESUL...

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