Jiro Kitaura

Publications : 0
Aldex : 0
H-index : 0
Citations : 0


Pharmacologic inhibition of Notch signaling suppresses food antigen–induced mucosal mast cell hyperplasia

Asuka Honjo et 12 al.

Mar 1, 2017 in Journal of Allergy and Clinical Immunology


The protective role of conjunctival goblet cell mucin sialylation.

Moe Matsuzawa, Jiro Kitaura et 19 al.

Mar 17, 2023 in Nature communications
Gel-forming mucins secreted by conjunctival goblet cells have been implicated in the clearance of allergens, pathogens, and debris. However, their roles remain incompletely understood. Here we show that human and mouse conjunctival goblet cell mucins have Alcian blue-detectable sialic acids, but not sulfates in the steady state. Interestingly, Balb/c mouse strain lacks this sialylation due to a po...


Development of mouse model for oral allergy syndrome to identify IgE cross-reactive pollen and food allergens: ragweed pollen cross-reacts with fennel and black pepper.

Anna Kamei, Jiro Kitaura et 15 al.

Jul 25, 2022 in Frontiers in immunology
Oral allergy syndrome (OAS) is an IgE-mediated immediate food allergy that is localized to the oral mucosa. Pollen food allergy syndrome (PFAS), a pollinosis-associated OAS, is caused by cross-reactivity between food and pollen allergens. However, we need to more precisely understand the underlying pathogenesis of OAS/PFAS. In the present study, we developed a method to comprehensively identify cr...


Tuning IgE: IgE-Associating Molecules and Their Effects on IgE-Dependent Mast Cell Reactions.

Tomoaki Ando, Jiro Kitaura

Jul 5, 2021 in Cells
The recent emergence of anti-immunoglobulin E (IgE) drugs and their candidates for humans has endorsed the significance of IgE-dependent pathways in allergic disorders. IgE is distributed locally in the tissues or systemically to confer a sensory mechanism in a domain of adaptive immunity to the otherwise innate type of effector cells, namely, mast cells and basophils. Bound on the high-affinity I...


Mucosal Mast Cells as Key Effector Cells in Food Allergies.

Nobuhiro Nakano, Jiro Kitaura

Jan 19, 2022 in Cells
Mucosal mast cells (MMCs) localized in the intestinal mucosa play a key role in the development of IgE-mediated food allergies. Recent advances have revealed that MMCs are a distinctly different population from connective tissue mast cells localized in skin and other connective tissues. MMCs are inducible and transient cells that arise from bone marrow-derived mast cell progenitors, and their numb...


Predictive value of 7S globulin-specific IgE in Japanese macadamia nut allergy patients.

Hiroki Yasudo, Yukihiro Ohya et 24 al.

Jan 21, 2022 in The journal of allergy and clinical immunology. In practice


Mucosal Mast Cell-Specific Gene Expression Is Promoted by Interdependent Action of Notch and TGF-β Signaling.

Nobuhiro Nakano, Ko Okumura et 11 al.

Nov 19, 2021 in Journal of immunology
Rodent mast cells are classified into two major subsets, mucosal mast cells (MMCs) and connective tissue mast cells. MMCs arise from mast cell progenitors that are mobilized from the bone marrow to mucosal tissues in response to allergic inflammation or helminth infection. TGF-β is known as an inducer of MMC differentiation in mucosal tissues, but we have previously found that Notch receptor-media...


Anti-CD321 antibody immunotherapy protects liver against ischemia and reperfusion-induced injury

Enzhi Yin et 11 al.

Jan 1, 2021 in Scientific Reports
The prognosis of the liver transplant patients was frequently deteriorated by ischemia and reperfusion injury (IRI) in the liver. Infiltration of inflammatory cells is reported to play critical roles in the pathogenesis of hepatic IRI. Although T lymphocytes, neutrophils and monocytes infiltrated into the liver underwent IRI, we found that neutrophil depletion significantly attenuated the injury a...


Techniques to Study FcεRI Signaling

Yuko Kawakami et 3 al.

Jan 1, 2006


IgE regulation of mast cell survival and function.

Toshiaki Kawakami, Yuko Kawakami et 3 al.

Jan 1, 2005 in Novartis Foundation symposium
Traditionally, it is thought that IgE binding to mast cells via the high-affinity receptor (FcepsilonRI) is simply a passive `sensitization` step prior to activation by receptor aggregation or cross-linking with multivalent antigen or other cross-linking agents. However, in addition to receptor up-regulation, recent studies have shown that monomeric IgE can induce survival and other activation eve...