Jing Chen

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Hierarchy Evolutionary Searching Algorithm for DNA Encoding Sequence

Lian Ye et 3 al.

Jan 1, 2010 in Applied Mechanics and Materials
DNA sequence design is the basic and important step for DNA computing. Good codeword could avoid some error may possibly occurred in practical computing. Therefore, much work has focused on designing the DNA sequences to make the molecular computation more reliable. In this paper, a new hierarchy evolutionary searching algorithm is proposed to obtain good DNA encoding sequences, this approach is b...

Engineering a dynamic three-dimensional cell culturing microenvironment using a 'sandwich' structure-liked microfluidic device with 3D printing scaffold.

Laiqian Ding, Jingmin Li et 11 al.

Sep 6, 2022 in Biofabrication
Most ofin vivotissue cells reside in 3D extracellular matrix (ECM) with fluid flow. To better study cell physiology and pathophysiology, there has been an increasing need in the development of methods for culturing cells inin vivolike microenvironments with a number of strategies currently being investigated including hydrogels, spheroids, tissue scaffolds and very promising microfluidic systems. ...

Sectm1a Facilitates Protection against Inflammation-Induced Organ Damage through Promoting TRM Self-Renewal.

Xingjiang Mu, Guo-Chang Fan et 10 al.

Mar 3, 2021 in Molecular therapy
Tissue-resident macrophages (TRMs) are sentinel cells for maintaining tissue homeostasis and organ function. In this study, we discovered that lipopolysaccharide (LPS) administration dramatically reduced TRM populations and suppressed their self-renewal capacities in multiple organs. Using loss- and gain-of-function approaches, we define Sectm1a as a novel regulator of TRM self-renewal. Specifical...

Temporal expression profiles of lncRNA and mRNA in human embryonic stem cell-derived motor neurons during differentiation.

Xue-Jiao Sun, Hong Chen et 8 al.

Nov 13, 2020 in PeerJ
Human embryonic stem cells (hESC) have been an invaluable research tool to study motor neuron development and disorders. However, transcriptional regulation of multiple temporal stages from ESCs to spinal motor neurons (MNs) has not yet been fully elucidated. Thus, the goals of this study were to profile the time-course expression patterns of lncRNAs during MN differentiation of ESCs and to clarif...

Relationship between heart rate variability and cognitive function in patients with enlarged perivascular space.

Dongyang Zhou, Qianqian Li et 7 al.

Nov 7, 2022 in Frontiers in aging neuroscience
To explore the relationship between heart rate variability (HRV), the brain distribution of enlarged perivascular space (EPVS), and cognitive impairment in patients with EPVS. The clinical and imaging data of 199 patients with EPVS were retrospectively analyzed. EPVS load in the basal ganglia (BG) and centrum semiovale (CS) regions were assessed using the Potter's method. Cognitive function was ev...

Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction(ThyroHeart-AMI)

Kuo Zhang, Yi-Da Tang et 3 al.

Jul 27, 2015 in ClinicalTrials.gov
Based on accumulating evidences showing that hypothyroid status is associated with poor prognosis among acute myocardial infarction (AMI) patients, the study is designed to evaluate whether replacement treatment with levothyroxine could have beneficial effects on patients with AMI and hypothyroidism. This is a multicenter prospective computerized-randomized trial stratified by ejection fraction wi...

Oral Calcitriol for Reduction of Mild Proteinuria in Patients With CKD

Li You, Jing Chen

Mar 19, 2013 in ClinicalTrials.gov
The safety and efficacy of Caltriol on mild proteinuria (<1.0g/d) reduction in CKD patients.

A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

Matthew A. Kutny et 179 al.

Feb 18, 2020 in ClinicalTrials.gov
This phase III trial compares standard chemotherapy to therapy with liposome-encapsulated daunorubicin-cytarabine (CPX-351) and/or gilteritinib for patients with newly diagnosed acute myeloid leukemia with or without FLT3 mutations. Drugs used in chemotherapy, such as daunorubicin, cytarabine, and gemtuzumab ozogamicin, work in different ways to stop the growth of cancer cells, either by killing t...

A Clinical Study of TK216 in Patients With Relapsed or Refractory Ewing's Sarcoma

Wei Guo, Binghao Li et 12 al.

Aug 24, 2021 in ClinicalTrials.gov
This study is a multicenter, single-arm, open-label Phase II clinical trial evaluating TK216 in combination with vincristine in the treatment of relapsed or refractory Ewing sarcoma (ES) including Ewing's sarcoma family tumors (ESFTs).

A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Matthew A. Kutny et 133 al.

Sep 11, 2020 in ClinicalTrials.gov
This phase II trial studies the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell acute lymphoblastic leukemia (B-ALL) that has come back (relapsed). Down syndrome patients with relapsed B-ALL are included in this study. Blinatumomab is an antibody, which is a protein that identifies and targets specific molecules in the body. Blin...