Alviss

Neurofilament light in biofluids has been associated with progression of Parkinson disease (PD), but the association between neurofilament heavy (NfH) and progression of PD has not been investigated. To evaluate the associations of cerebrospinal fluid (CSF) NfH (cNfH) levels and motor and cognitive progression in PD. This cohort study used data from the Parkinson Progression Marker Initiative rang...

Subjective or objective subtle cognitive decline (SCD) is considered the preclinical manifestation of Alzheimer"s disease (AD), which is a potentially crucial window for preventing or delaying the progression of the disease. To explore the potential mechanism of disease progression and identify relevant biomarkers, we comprehensively assessed the peripheral blood transcriptomic alterations in SCD,...

The effective connectivity between 21 regions in the human posterior parietal cortex, and 360 cortical regions was measured in 171 Human Connectome Project (HCP) participants using the HCP atlas, and complemented with functional connectivity and diffusion tractography. Intraparietal areas LIP, VIP, MIP, and AIP have connectivity from early cortical visual regions, and to visuomotor regions such as...

To advance understanding of brain networks involved in language, the effective connectivity between 26 cortical regions implicated in language by a community analysis and 360 cortical regions was measured in 171 humans from the Human Connectome Project, and complemented with functional connectivity and diffusion tractography, all using the HCP multimodal parcellation atlas. A (semantic) network (G...

The effective connectivity between 55 visual cortical regions and 360 cortical regions was measured in 171 HCP participants using the HCP-MMP atlas, and complemented with functional connectivity and diffusion tractography. A Ventrolateral Visual "What" Stream for object and face recognition projects hierarchically to the inferior temporal visual cortex, which projects to the orbitofrontal cortex f...

IJERPH, Vol. 19, Pages 8412: Effects of Environmental Concentrations of Total Phosphorus on the Plankton Community Structure and Function in a Microcosm Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph19148412 Authors: Xue Bai Zhendong Jiang Yuan Fang Lin Zhu Jianfeng Feng The excessive nutrients in freshwater have been proven to promote eutrophication an...

Based upon the moment closure approach, a Gaussian random field is constructed to quantitatively and analytically characterize the dynamics of a random point field. The approach provides us with a theoretical tool to investigate synchronized spike propagation in a feedforward or recurrent spiking neural network. We show that the balance between the excitation and inhibition postsynaptic potentials...

Objective To investigate the independent associations of social isolation and loneliness with incident dementia and to explore the potential neurobiological mechanisms. Method We utilized the UK Biobank cohort to establish Cox proportional hazard models with social isolation and loneliness as separate exposures. Demographic (sex, age and ethnicity), socioeconomic (education level, household incom...

Background and Objective : To investigate relationship between baseline structural measurements of brain reserve and clinical progression in Parkinsons disease (PD). To further provide a possible underlying mechanism for structural measurements of brain reserve in PD, we combined functional and transcriptional data and investigated its relationship with progression associated patterns derived from...