Ji Young Mun

Publications : 71
Aldex : 40
H-index : 21
Citations : 1169

Supersaturation-controlled microcrystallization and visualization analysis for serial femtosecond crystallography

Dan Bi Lee et 20 al.

Feb 7, 2018 in Scientific Reports
Time-resolved serial femtosecond crystallography with X-ray free electron laser (XFEL) holds the potential to view fast reactions occurring at near-physiological temperature. However, production and characterization of homogeneous micron-sized protein crystals at high density remain a bottleneck, due to the lack of the necessary equipments in ordinary laboratories. We describe here supersaturation...

Photo-Cross-Linkable Human Albumin Colloidal Gels Facilitate In Vivo Vascular Integration for Regenerative Medicine.

Heejeong Yoon, Hojae Bae et 16 al.

Dec 14, 2021 in ACS omega
Biodegradable cellular and acellular scaffolds have great potential to regenerate damaged tissues or organs by creating a proper extracellular matrix (ECM) capable of recruiting endogenous cells to support cellular ingrowth. However, since hydrogel-based scaffolds normally degrade through surface erosion, cell migration and ingrowth into scaffolds might be inhibited early in the implantation. This...

medicine

Double staining method for array tomography using scanning electron microscopy

Eunjin Kim, Ji Young Mun et 4 al.

Jan 1, 2020 in Applied Microscopy
Scanning electron microscopy (SEM) plays a central role in analyzing structures by imaging a large area of brain tissue at nanometer scales. A vast amount of data in the large area are required to study structural changes of cellular organelles in a specific cell, such as neurons, astrocytes, oligodendrocytes, and microglia among brain tissue, at sufficient resolution. Array tomography is a useful...

chemistry

Direct Visualization of Actin Filaments and Actin-Binding Proteins in Neuronal Cells

Minkyo Jung, Ji Young Mun et 2 al.

Jan 1, 2020 in Frontiers in Cell and Developmental Biology
Actin networks and actin-binding proteins (ABPs) are most abundant in the cytoskeleton of neurons. The function of ABPs in neurons is nucleation of actin polymerization, polymerization or depolymerization regulation, bundling of actin through crosslinking or stabilization, cargo movement along actin filaments, and anchoring of actin to other cellular components. In axons, ABP–actin interaction for...


biology

Techniques and applications of three‐dimensional electron microscopy in entomological research

Min Kyo Jung, Ji Young Mun et 2 al.

Jan 1, 2016 in Entomological Research
Structural studies using two‐dimensional (2D) images show limitations in understanding the structure and functions of cellular organelle and protein. To overcome the difficulty, over the last few years 3D reconstruction techniques using electron microscopy have been developed at extremely high speed. In this paper, currently available 3D reconstruction techniques of electron microscopy (such as el...

medicine

Der p 38 is a bidirectional regulator of eosinophils and neutrophils in allergy

Min Hwa Hong, In Sik Kim et 13 al.

Jan 1, 2020
Background : The house dust mite (HDM) is the most common cause of allergic diseases, and TLR4 acts as an overarching receptor for allergic responses. This study aimed to identify novel allergen binding to TLR4 in HDMs and unveil its unique role in allergic responses. Method : Der p 38 was purified and characterized by LC-MS/MS-based peptide mapping. Biolayer interferometry and structure modeling...

medicine

Ultrastructural Study of Keratinocytes and Melanocytes in Seborrheic Keratosis

Seulgi Noh, Ji Young Mun et 3 al.

Jan 1, 2018 in Biophysical Journal

biology

Neuromyelitis optica (NMO)-IgG-driven organelle reorganization in human iPSC-derived astrocytes.

Sukhee Cho, Ji Young Mun et 9 al.

Oct 1, 2021 in FASEB journal
Neuromyelitis optica (NMO) is an autoimmune disease that primarily targets astrocytes. Autoantibodies (NMO-IgG) against the water channel protein, aquaporin 4 (AQP4), are a serologic marker in NMO patients, and they are known to be responsible for the pathophysiology of the disease. In the brain, AQP4 is mainly expressed in astrocytes, especially at the end-feet, where they form the blood-brain ba...

genetics

Autophagic defects observed in fibroblasts from a patient with β‐propeller protein‐associated neurodegeneration

Jae‐Hyeok Lee, Ji Young Mun et 7 al.

Jul 29, 2021 in American Journal of Medical Genetics Part A
Beta‐propeller protein‐associated neurodegeneration (BPAN) is associated with mutations in the autophagy gene WDR45. The aim of this study was to demonstrate autophagic defects in a patient with BPAN. We assayed autophagic markers using western blot analysis and immunocytochemistry and applied transmission electron microscopy (TEM) to visualize the autophagic structures in fibroblasts from a 7‐ye...

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