Hong-Zhong Gou

Publications : 3
Aldex : 0
H-index : 1
Citations : 1

The gut microbiota–bile acid axis: A potential therapeutic target for liver fibrosis

Yu-Lin Zhang, Lei Zhang et 4 al.

Sep 15, 2022 in Frontiers in Cellular and Infection Microbiology
Liver fibrosis involves the proliferation and deposition of extracellular matrix on liver tissues owing to various etiologies (including viral, alcohol, immune, and metabolic factors), ultimately leading to structural and functional abnormalities in the liver. If not effectively treated, liver fibrosis, a pivotal stage in the path to chronic liver disease, can progress to cirrhosis and eventually ...

gastroenterology

Role of intestinal flora in primary sclerosing cholangitis and its potential therapeutic value

Zhen-Jiao Li, Lei Zhang et 4 al.

Nov 28, 2022 in World Journal of Gastroenterology
Primary sclerosing cholangitis (PSC) is an autoimmune disease characterized by chronic cholestasis, a persistent inflammation of the bile ducts that leads to sclerotic occlusion and cholestasis. Gut microbes, consisting of microorganisms colonized in the human gut, play an important role in nutrient intake, metabolic homeostasis, immune regulation, and immune regulation; however, their presence m...

How do intestinal probiotics restore the intestinal barrier?

Hong-Zhong Gou, Lei Zhang et 4 al.

Jul 14, 2022 in Frontiers in microbiology
The intestinal barrier is a structure that prevents harmful substances, such as bacteria and endotoxins, from penetrating the intestinal wall and entering human tissues, organs, and microcirculation. It can separate colonizing microbes from systemic tissues and prevent the invasion of pathogenic bacteria. Pathological conditions such as shock, trauma, stress, and inflammation damage the intestinal...

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