Holly Joyce

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Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma.

Takuya Kato, Erik Sahai et 11 al.

Mar 9, 2023 in eLife
Cancers, such as squamous cell carcinoma, frequently invade as multicellular units. However, these invading units can be organised in a variety of ways, ranging from thin discontinuous strands to thick 'pushing' collectives. Here we employ an integrated experimental and computational approach to identify the factors that determine the mode of collective cancer cell invasion. We find that matrix pr...


Association between peri-operative angiotensin-converting enzyme inhibitors and angiotensin-2 receptor blockers and acute kidney injury in major elective non-cardiac surgery: a multicentre, prospective cohort study

Thomas M Drake, O Coldicutt et 499 al.

Jul 9, 2018 in Anaesthesia
The peri‐operative use of angiotensin‐converting enzyme inhibitors or angiotensin‐2 receptor blockers is thought to be associated with an increased risk of postoperative acute kidney injury. To reduce this risk, these agents are commonly withheld during the peri‐operative period. This study aimed to investigate if withholding angiotensin‐converting enzyme inhibitors or angiotensin‐2 receptor block...


Safety of Percutaneous Dilatational Tracheostomy During Veno-Venous Extracorporeal Membrane Oxygenation Support in Adults With Severe Respiratory Failure

Stavros Dimopoulos et 10 al.

Nov 1, 2018 in Critical Care Medicine
Objective : To investigate the safety of percutaneous dilatational tracheostomy in severe respiratory failure patients during veno-venous extracorporeal membrane oxygenation support. Design : A single-center, retrospective, observational cohort study. Setting: Tertiary referral severe respiratory failure center, university teaching hospital. Patients: Severe respiratory failure patients consecuti...


Students` participation in collaborative research should be recognised

Aditya Borakati et 912 al.

Mar 1, 2017 in International Journal of Surgery


Precise treatment of cystic fibrosis – current treatments and perspectives for using CRISPR

Josie Colemeadow et 3 al.

Feb 16, 2016 in Expert Review of Precision Medicine and Drug Development