Hideoki Ogawa

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Human β-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes

Rithee Smithrithee, Hideoki Ogawa et 6 al.

Jan 1, 2015 in Journal of Dermatological Science


Inhibition of IgE-mediated allergic reactions by pharmacologically targeting the circadian clock.

Yuki Nakamura et 11 al.

Nov 11, 2015 in The Journal of allergy and clinical immunology
The circadian clock temporally gates signaling through the high-affinity IgE receptor (FcεRI) in mast cells, thereby generating a marked day/night variation in allergic reactions. Thus manipulation of the molecular clock in mast cells might have therapeutic potential for IgE-mediated allergic reactions. We determined whether pharmacologically resetting the molecular clock in mast cells or basophil...

Clock-dependent temporal regulation of IL-33/ST2-mediated mast cell response.

Takahiro Kawauchi et 9 al.

Mar 2, 2017 in Allergology international
Interleukin-33 (IL-33) is an alarmin cytokine that binds to the interleukin 1 receptor-like 1 protein ST2. Clock is a key circadian gene that is essential for endogenous clockworks in mammals. This study investigated whether Clock temporally regulated IL-33-mediated responses in mast cells. The kinetics of IL-33-mediated IL-6, IL-13, and TNF-α productions were compared between bone marrow-derived ...

The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions.

François Niyonsaba et 6 al.

Apr 24, 2013 in Journal of leukocyte biology
Although HDPs were originally hypothesized to act as antimicrobial agents, they also have been shown to broadly modulate the immune response through the activation of different cell types. We recently developed a series of novel, synthetic peptides, termed IDRs, which are conceptually based on a natural HDP, bovine bactenecin. We showed that IDR-1 and IDR-1002 protect the host against bacterial in...


The protective role of conjunctival goblet cell mucin sialylation.

Moe Matsuzawa, Jiro Kitaura et 19 al.

Mar 17, 2023 in Nature communications
Gel-forming mucins secreted by conjunctival goblet cells have been implicated in the clearance of allergens, pathogens, and debris. However, their roles remain incompletely understood. Here we show that human and mouse conjunctival goblet cell mucins have Alcian blue-detectable sialic acids, but not sulfates in the steady state. Interestingly, Balb/c mouse strain lacks this sialylation due to a po...

IJMS, Vol. 24, Pages 5200: The Antimicrobial Peptide AMP IBP5 Suppresses Dermatitis like Lesions in a Mouse Model of Atopic Dermatitis through the Low Density Lipoprotein Receptor Related Protein 1 Receptor

Hai Le Thanh Nguyen et 11 al.

Mar 8, 2023 in International Journal of Molecular Sciences
IJMS, Vol. 24, Pages 5200: The Antimicrobial Peptide AMP IBP5 Suppresses Dermatitis like Lesions in a Mouse Model of Atopic Dermatitis through the Low Density Lipoprotein Receptor Related Protein 1 Receptor International Journal of Molecular Sciences doi: 10.3390/ijms24065200 Authors: Hai Le Thanh Nguyen Ge Peng Juan Valentin Trujillo Paez Hainan Yue Risa Ikutama Miho Takahashi Yoshie Umehara Ko O...

Innate IL-17A Enhances IL-33-Independent Skin Eosinophilia and IgE Response on Subcutaneous Papain Sensitization.

Seiji Kamijo, Toshiro Takai et 6 al.

May 26, 2020 in The Journal of investigative dermatology
IL-33-activated group 2 innate lymphoid cells critically contribute to protease allergen-induced airway inflammation models. However, IL-33 is dispensable for a subcutaneous (s.c.) papain-induced skin inflammation model, suggesting distinct mechanisms between intranasal and s.c. sensitization. Here, we examined the role of IL-17A in the s.c. model. Papain-exposed skin produced IL-17A and an excess...


Development of mouse model for oral allergy syndrome to identify IgE cross-reactive pollen and food allergens: ragweed pollen cross-reacts with fennel and black pepper.

Anna Kamei, Jiro Kitaura et 15 al.

Jul 25, 2022 in Frontiers in immunology
Oral allergy syndrome (OAS) is an IgE-mediated immediate food allergy that is localized to the oral mucosa. Pollen food allergy syndrome (PFAS), a pollinosis-associated OAS, is caused by cross-reactivity between food and pollen allergens. However, we need to more precisely understand the underlying pathogenesis of OAS/PFAS. In the present study, we developed a method to comprehensively identify cr...


Betacellulin is downregulated in plaque psoriasis and may reflect disease severity

Ge Peng et 9 al.

Jul 16, 2022 in Journal of the European Academy of Dermatology and Venereology
Journal of the European Academy of Dermatology and Venereology, Accepted Article.