Guoqing Qian

Publications : 71
Aldex : 40
H-index : 20
Citations : 924

medicine

Cryptococcosis as a complication of therapy for sarcoidosis: A case report

Jiejun Shi, Guoqing Qian et 5 al.

Oct 19, 2021 in SAGE Open Medical Case Reports
SAGE Open Medical Case Reports, Volume 9, Issue , January December 2021. Cryptococcosis is a rare complication of sarcoidosis, especially when it grows in lungs. It may escape from being diagnosed because of low prevalence and non specific radiological presentation. Hereby, we reported an unusual case of pulmonary cryptococcosis secondary to the long term use of glucocorticoids to treat sarcoidosi...

Serum uric acid to creatinine ratio is associated with higher prevalence of NAFLD detected by FibroScan in the United States

Rusha Wang, Xueqin Chen et 6 al.

Jul 8, 2022 in Journal of Clinical Laboratory Analysis
sUA/Cr was positively associated with NAFLD. Background The association between the serum uric acid (sUA) to creatinine ratio (sUA/Cr) and non alcoholic fatty liver disease (NAFLD) has not been sufficiently clarified. In this study, we investigated the relationship between sUA/Cr and NAFLD among participants in the United States. Method We performed a cross sectional study based on data from...

medicine

Association Between Monocyte to High-Density Lipoprotein Cholesterol Ratio and Risk of Non-alcoholic Fatty Liver Disease: A Cross-Sectional Study.

Liping Wang, Guoqing Qian et 5 al.

May 19, 2022 in Frontiers in medicine
Non-alcoholic fatty liver disease (NAFLD) is a global health problem affecting more than a quarter of the entire adult population. Both monocytes and high-density lipoprotein cholesterol (HDL-C) were found to participate in the progression of hepatic inflammation and oxidative stress. We speculated that the monocyte-to-HDL-C ratio (MHR) may be associated with the risk of NAFLD. We conducted a cros...

health

Age Specific Transmissibility Change of COVID 19 and Associations With Breathing Air Volume, Preexisting Immunity, and Government Response

Qifa Song, Guoqing Qian et 4 al.

Mar 15, 2022 in Frontiers in Public Health
Background The comprehensive impacts of diverse breathing air volumes and preexisting immunity on the host susceptibility to and transmission of COVID 19 at various pandemic stages have not been investigated. Method We classified the US weekly COVID 19 data into 0–4, 5–11, 12–17, 18–64, and 65+ age groups and applied the odds ratio (OR) of incidence between one age group and the 18–64 age group t...

Dedicator of Cytokinesis 2 (DOCK2) Deficiency Attenuates Lung Injury Associated with Chronic High-Fat and High-Fructose Diet-Induced Obesity.

Guoqing Qian, Xia Guo et 7 al.

Nov 10, 2021 in The American journal of pathology
Obesity is a major risk factor for lung disease development. However, little is known about the impact of chronic high-fat and high-fructose (HFHF) diet-induced obesity on lung inflammation and subsequent pulmonary fibrosis. Herein we hypothesized that dedicator of cytokinesis 2 (DOCK2) promotes a proinflammatory phenotype of lung fibroblasts (LFs) to elicit lung injury and fibrosis in chronic HFH...

biology

Abdominal Aortic Aneurysm Formation with a Focus on Vascular Smooth Muscle Cells.

Guoqing Qian, Xia Guo et 3 al.

Jan 27, 2022 in Life
Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects, mostly, the elder population, with a high mortality rate (>80%) upon rupture. It features a dilation of the aortic diameter to larger than 30 mm or more than 50%. Diverse pathological processes are involved in the development of AAA, including aortic wall inflammation, elastin breakdown, oxidative stress, smoot...

biology

Life, Vol. 12, Pages 191: Abdominal Aortic Aneurysm Formation with a Focus on Vascular Smooth Muscle Cells

Guoqing Qian, Xia Guo et 3 al.

Jan 27, 2022 in Life
Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects, mostly, the elder population, with a high mortality rate (>80%) upon rupture. It features a dilation of the aortic diameter to larger than 30 mm or more than 50%. Diverse pathological processes are involved in the development of AAA, including aortic wall inflammation, elastin breakdown, oxidative stress, smoot...

medicine

Obesity and the Development of Lung Fibrosis.

Xia Guo, Guoqing Qian et 2 al.

Jan 10, 2022 in Frontiers in pharmacology
Obesity is an epidemic worldwide and the obese people suffer from a range of respiratory complications including fibrotic changes in the lung. The influence of obesity on the lung is multi-factorial, which is related to both mechanical injury and various inflammatory mediators produced by excessive adipose tissues, and infiltrated immune cells. Adiposity causes increased production of inflammatory...

biology

Characterization of a Novel Mouse Model of Spontaneous Human Lung Cancer Metastasis

Dong M. Shin, Susan Muller et 6 al.

Jan 1, 2019 in Computers & Operations Research
To identify new strategies against lung metastasis and understand the underlying mechanisms, a highly metastatic pulmonary large cell carcinoma cell line model (801BL) was established through two rounds of in vivo selection using a nude mouse xenograft model. Satellite tandem repeat (STR) analysis confirmed the same genomic background of the newly established metastatic cell line 801BL as the non-...

biology

Abstract 4598: mTORC2 suppresses GSK3-dependent, but b-TrCP-independent, Snail degradation, contributing to positive regulation of cancer cell invasion and metastasis

Shuo Zhang, Shi-Yong Sun et 8 al.

Jan 1, 2019 in Cancer Research
Mammalian target of rapamycin (mTOR) complex 1 (mTORC1) positively regulates cell invasion and metastasis via enhancing Snail protein translation. The connection between mTOR complex 2 (mTORC2) and cell invasion and metastasis has also been suggested. However the underlying biology or mechanism is largely unknown and thus is the focus of this study. Inhibition of mTOR with both mTOR inhibitors and...

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