Guoqing Qian

Publications : 74
Aldex : 40
H-index : 20
Citations : 930

medicine

Cryptococcosis as a complication of therapy for sarcoidosis: A case report

Jiejun Shi, Guoqing Qian et 5 al.

Oct 19, 2021 in SAGE Open Medical Case Reports
SAGE Open Medical Case Reports, Volume 9, Issue , January December 2021. Cryptococcosis is a rare complication of sarcoidosis, especially when it grows in lungs. It may escape from being diagnosed because of low prevalence and non specific radiological presentation. Hereby, we reported an unusual case of pulmonary cryptococcosis secondary to the long term use of glucocorticoids to treat sarcoidosi...

biology

miR 378 associated with proliferation, migration and apoptosis properties in A549 cells and targeted NPNT in COPD

Guoqing Qian, Fengying Yin et 3 al.

Sep 15, 2022 in PeerJ
Background microRNAs contribute to the development and progression of chronic obstructive pulmonary disease (COPD). However, the underlying molecular mechanisms are largely unclear. The goal of this study was to investigate the roles of miR 378 in alveolar epithelial type II cells and identify molecular mechanisms which contribute to the pathogenesis of COPD. Materials and methods Human alveolar ...

Clinical and Pulmonary CT Characteristics of Patients Infected With the SARS-CoV-2 Omicron Variant Compared With Those of Patients Infected With the Alpha Viral Strain.

Naibin Yang, Guoqing Qian et 9 al.

Jul 12, 2022 in Frontiers in public health
Omicron has become the dominant variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) globally. We aimed to compare the clinical and pulmonary computed tomography (CT) characteristics of the patients infected with SARS-CoV-2 Omicron with those of patients infected with the Alpha viral strain. Clinical profiles and pulmonary CT images of 420 patients diagnosed with coronavirus dis...

Serum uric acid to creatinine ratio is associated with higher prevalence of NAFLD detected by FibroScan in the United States

Rusha Wang, Xueqin Chen et 6 al.

Jul 8, 2022 in Journal of Clinical Laboratory Analysis
sUA/Cr was positively associated with NAFLD. Background The association between the serum uric acid (sUA) to creatinine ratio (sUA/Cr) and non alcoholic fatty liver disease (NAFLD) has not been sufficiently clarified. In this study, we investigated the relationship between sUA/Cr and NAFLD among participants in the United States. Method We performed a cross sectional study based on data from...

medicine

Association Between Monocyte to High-Density Lipoprotein Cholesterol Ratio and Risk of Non-alcoholic Fatty Liver Disease: A Cross-Sectional Study.

Liping Wang, Guoqing Qian et 5 al.

May 19, 2022 in Frontiers in medicine
Non-alcoholic fatty liver disease (NAFLD) is a global health problem affecting more than a quarter of the entire adult population. Both monocytes and high-density lipoprotein cholesterol (HDL-C) were found to participate in the progression of hepatic inflammation and oxidative stress. We speculated that the monocyte-to-HDL-C ratio (MHR) may be associated with the risk of NAFLD. We conducted a cros...

health

Age Specific Transmissibility Change of COVID 19 and Associations With Breathing Air Volume, Preexisting Immunity, and Government Response

Qifa Song, Guoqing Qian et 4 al.

Mar 15, 2022 in Frontiers in Public Health
Background The comprehensive impacts of diverse breathing air volumes and preexisting immunity on the host susceptibility to and transmission of COVID 19 at various pandemic stages have not been investigated. Method We classified the US weekly COVID 19 data into 0–4, 5–11, 12–17, 18–64, and 65+ age groups and applied the odds ratio (OR) of incidence between one age group and the 18–64 age group t...

Dedicator of Cytokinesis 2 (DOCK2) Deficiency Attenuates Lung Injury Associated with Chronic High-Fat and High-Fructose Diet-Induced Obesity.

Guoqing Qian, Xia Guo et 7 al.

Nov 10, 2021 in The American journal of pathology
Obesity is a major risk factor for lung disease development. However, little is known about the impact of chronic high-fat and high-fructose (HFHF) diet-induced obesity on lung inflammation and subsequent pulmonary fibrosis. Herein we hypothesized that dedicator of cytokinesis 2 (DOCK2) promotes a proinflammatory phenotype of lung fibroblasts (LFs) to elicit lung injury and fibrosis in chronic HFH...

biology

Abdominal Aortic Aneurysm Formation with a Focus on Vascular Smooth Muscle Cells.

Guoqing Qian, Xia Guo et 3 al.

Jan 27, 2022 in Life
Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects, mostly, the elder population, with a high mortality rate (>80%) upon rupture. It features a dilation of the aortic diameter to larger than 30 mm or more than 50%. Diverse pathological processes are involved in the development of AAA, including aortic wall inflammation, elastin breakdown, oxidative stress, smoot...

biology

Life, Vol. 12, Pages 191: Abdominal Aortic Aneurysm Formation with a Focus on Vascular Smooth Muscle Cells

Guoqing Qian, Xia Guo et 3 al.

Jan 27, 2022 in Life
Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects, mostly, the elder population, with a high mortality rate (>80%) upon rupture. It features a dilation of the aortic diameter to larger than 30 mm or more than 50%. Diverse pathological processes are involved in the development of AAA, including aortic wall inflammation, elastin breakdown, oxidative stress, smoot...

medicine

Obesity and the Development of Lung Fibrosis.

Xia Guo, Guoqing Qian et 2 al.

Jan 10, 2022 in Frontiers in pharmacology
Obesity is an epidemic worldwide and the obese people suffer from a range of respiratory complications including fibrotic changes in the lung. The influence of obesity on the lung is multi-factorial, which is related to both mechanical injury and various inflammatory mediators produced by excessive adipose tissues, and infiltrated immune cells. Adiposity causes increased production of inflammatory...

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