Erik J. Plautz

Publications : 20
Aldex : 30
H-index : 12
Citations : 1768


LZK dependent stimulation of astrocyte reactivity promotes corticospinal axon sprouting

Meifan Chen et 9 al.

Sep 15, 2022 in Frontiers in Cellular Neuroscience
Injury to the adult mammalian central nervous system induces compensatory plasticity of spared axons—referred to as collateral axon sprouting—that can facilitate neural recovery. The contribution of reactive astrocytes to axon sprouting remains elusive. Here, we sought to investigate the role of axon degeneration reactive astrocytes in the regulation of collateral axon sprouting that occurs in the...

Reorganization of Ventral Premotor Cortex After Ischemic Brain Injury: Effects of Forced Use

Shawn B. Frost et 6 al.

May 13, 2022 in Neurorehabilitation and Neural Repair
Neurorehabilitation and Neural Repair, Ahead of Print. Background Physical use of the affected upper extremity can have a beneficial effect on motor recovery in people after stroke. Few studies have examined neurological mechanisms underlying the effects of forced use in non human primates. In particular, the ventral premotor cortex (PMV) has been previously implicated in recovery after injury. ...


Mutant screen for reproduction unveils depression-associated Piccolo’s control over reproductive behavior

Gerardo A. Medrano, F. Kent Hamra et 17 al.

Jan 1, 2020 in bioRxiv
Successful sexual reproduction involves complex, genetically encoded interplay between animal physiology and behavior. The rat provides a highly fecund mammalian model for studying how the brain impacts reproduction. Here, we report a forward genetics screen in rats to identify genes that affect reproduction. A panel of 18 distinct rat strains harboring Sleeping Beauty gene trap mutations were ana...


Loss of Piccolo function in rats induces Pontocerebellar Hypoplasia type 3-like phenotypes

Joanne Falck et 15 al.

Jan 1, 2019 in bioRxiv
Piccolo, a presynaptic active zone protein, is best known for its role in the regulated assembly and function of vertebrate synapses. Genetic studies suggest a further link to several psychiatric disorders as well as Pontocerebellar Hypoplasia type 3 (PCH3), although a causal relationship is lacking. We have characterized recently generated knockout (Pclogt/gt) rats. Analysis revealed a dramatic r...

Role of adaptive plasticity in recovery of function after damage to motor cortex

Randolph J. Nudo et 3 al.

Jan 1, 2001 in Muscle & Nerve
Based upon neurophysiologic, neuroanatomic, and neuroimaging studies conducted over the past two decades, the cerebral cortex can now be viewed as functionally and structurally dynamic. More specifically, the functional topography of the motor cortex (commonly called the motor homunculus or motor map), can be modified by a variety of experimental manipulations, including peripheral or central inju...

Behavioral and neurophysiological effects of delayed training following a small ischemic infarct in primary motor cortex of squirrel monkeys

Scott Barbay et 7 al.

Nov 5, 2005 in Experimental Brain Research
A focal injury within the cerebral cortex results in functional reorganization within the spared cortex through time-dependent metabolic and physiological reactions. Physiological changes are also associated with specific post-injury behavioral experiences. Knowing how these factors interact can be beneficial in planning rehabilitative intervention after a stroke. The purpose of this study was to ...


Somatosensory and motor representations in cerebral cortex of a primitive mammal (Monodelphis domestica): A window into the early evolution of sensorimotor cortex

Shawn B. Frost et 5 al.

May 22, 2000 in The Journal of Comparative Neurology
To examine the potential early stages in the evolution of sensorimotor cortex, electrophysiological studies were conducted in the primitive South American marsupial opossum, Monodelphis domestica. Somatosensory maps derived from multiunit microelectrode recordings revealed a complete somatosensory representation of the contralateral body surface within a large region of midrostral cortex (primary ...


Adaptive Plasticity in Primate Motor Cortex as a Consequence of Behavioral Experience and Neuronal Injury

Randolph J. Nudo et 3 al.

Jan 1, 1997 in Seminars in Neuroscience
It is now clear that the motor cortex of adult mammals is capable of widespread functional reorganization. After specific types of motor skill training, the cortical representations of the movements used to perform the task expand, invading adjacent motor representations. After peripheral nerve injury, representations of unaffected muscles expand, invading those of the denervated muscles. After f...

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