Ding Qiu

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Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression.

Ce Tang et 19 al.

Mar 17, 2023 in Nature communications
Dectin-1 (gene Clec7a), a receptor for β-glucans, plays important roles in the host defense against fungi and immune homeostasis of the intestine. Although this molecule is also suggested to be involved in the regulation of tumorigenesis, the role in intestinal tumor development remains to be elucidated. In this study, we find that azoxymethane-dextran-sodium-sulfate-induced and ApcMin-induced int...


A Pandas complex adapted for piRNA-guided transposon silencing

Kang Zhao, Yang Yu et 21 al.

Jan 1, 2019 in bioRxiv
The repression of transposons by the Piwi-interacting RNA (piRNA) pathway is essential to protect animal germ cells. In Drosophila ovaries, Panoramix (Panx) enforces transcriptional silencing by binding to the target-engaged Piwi-piRNA complex, although the precise mechanisms by which this occur remain elusive. Here, we show that Panx functions together with a germline specific paralogue of a nucl...

GoldCLIP: Gel-omitted Ligation-dependent CLIP

Jiaqi Gu, Yang Yu et 8 al.

Apr 1, 2018 in Genomics, Proteomics & Bioinformatics
Protein–RNA interaction networks are essential to understand gene regulation control. Identifying binding sites of RNA-binding proteins (RBPs) by the UV-crosslinking and immunoprecipitation (CLIP) represents one of the most powerful methods to map protein–RNA interactions in vivo. However, the traditional CLIP protocol is technically challenging, which requires radioactive labeling and suffers fro...

The Brachypodium distachyon BdWRKY36 gene confers tolerance to drought stress in transgenic tobacco plants

Jiutong Sun et 11 al.

Sep 16, 2014 in Plant Cell Reports
Key messageThe expression ofBdWRKY36was upregulated by drought treatment. BdWRKY36-overexpressing transgenic tobacco increased drought tolerance by controlling ROS homeostasis and regulating transcription of stress related genes. WRKY transcription factor plays important roles in plant growth, development and stress response. However, the function of group IIe WRKYs is less known. In this study, ...

TaSnRK2.9, a Sucrose Non-fermenting 1-Related Protein Kinase Gene, Positively Regulates Plant Response to Drought and Salt Stress in Transgenic Tobacco

Jialu Feng, Guangyuan He et 11 al.

Jan 14, 2019 in Frontiers in Plant Science
Sucrose non-fermenting 1-related protein kinase 2 (SnRK2) family members play crucial roles in plant abiotic stress response. However, the precise mechanism underlying the function of SnRKs has not been thoroughly elucidated in plants. In this research, a novel SnRK2 gene, TaSnRK2.9 was cloned and characterized from common wheat. The expression of TaSnRK2.9 was upregulated by polyethylene glycol (...