Daliao Xiao

Publications : 51
Aldex : 30
H-index : 19
Citations : 840


Single nucleus chromatin accessibility and RNA sequencing reveal impaired brain development in prenatally e cigarette exposed neonatal rats

Zhong Chen, Charles Wang et 5 al.

Jun 29, 2022 in iScience
Although emerging evidence reveals that vaping alters the function of the central nervous system, the effects of maternal vaping on offspring brain development remain elusive. Using a well established in utero exposure model, we performed single nucleus ATAC seq (snATAC seq) and RNA sequencing (snRNA seq) on prenatally e cigarette exposed rat brain. We found that maternal vaping distorted neuronal...

IJMS, Vol. 23, Pages 6885: The Regulatory Role of H19/miR 181a/ATG5 Signaling in Perinatal Nicotine Exposure Induced Development of Neonatal Brain Hypoxic Ischemic Sensitive Phenotype

Yong Li, Daliao Xiao et 6 al.

Jun 21, 2022 in International Journal of Molecular Sciences
(This summary has been generated by AI. Generate your own summaries: https://www.welcome.alviss.ai/alboard/#/editorial) Background : previous studies revealed that perinatal nicotine exposure programs a sensitive phenotype to neonatal hypoxic ischemic encephalopathy in postnatal life, yet the underlying mechanisms remain undetermined. The goal of the present study was to determine the regulatory...


Cardiovascular Adaptation to High-Altitude Hypoxia

Jun Ke, Daliao Xiao et 2 al.

Jan 1, 2017
High-altitude exposure has been well recognized as a hypoxia exposure that significantly affects cardiovascular function. However, the pathophysiologic adaptation of cardiovascular system to high-altitude hypoxia (HAH) varies remarkably. It may depend on the exposed time and oxygen partial pressure in the altitude place. In short-term HAH, cardiovascular adaptation is mainly characterized by funct...


Therapeutic Implication of miRNA in Human Disease

Andrew Walayat, Daliao Xiao et 2 al.

Jan 1, 2018
MicroRNAs (miRNAs) are a class of short non-coding RNA molecules that are involved in development and diseases. Early studies are focusing on the miRNA profile as a biomarker in disease. As discovery of human miRNAs increased in the setting of disease, the research focus was gradually shifted towards miRNA therapeutic strategy for diagnostic and treatment of disease. Increasing evidences suggest t...

Inhibition of DNA methylation in newborns reprograms ischemia-sensitive biomarkers resulting in development of a heart ischemia-sensitive phenotype late in life.

Yanyan Zhang, Daliao Xiao et 5 al.

Sep 15, 2021 in Reproductive toxicology
Adverse environmental stress exposure at critical perinatal stages can alter cardiovascular development, which could persist into adulthood and develop a cardiovascular dysfunctional phenotype late in life. However, the underlying molecular mechanisms remain largely unknown. The present study provided a direct evidence that DNA methylation is a key epigenetic mechanism contributing to the developm...

Fetal e-cigarette exposure programs a neonatal brain hypoxic-ischemic sensitive phenotype via altering DNA methylation patterns and autophagy signaling pathway.

Andrew Walayat, Daliao Xiao et 7 al.

Sep 15, 2021 in American journal of physiology. Regulatory, integrative and comparative physiology
Maternal e-cigarette (e-cig) exposure is a pressing perinatal health concern. Emerging evidence reveals its potential adverse impacts on brain development in offspring, yet the underlying mechanisms are poorly understood. The present study tested the hypothesis that fetal e-cig exposure induces an aberrant DNA methylation profiles in the developing brain, leading to alteration of autophagic flux s...

Pregnancy enhances endothelium-dependent relaxation of ovine uterine artery: role of NO and intracellular Ca2 plus

Daliao Xiao, Lubo Zhang et 2 al.

Jul 1, 2001 in American Journal of Physiology-Heart and Circulatory Physiology

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