Alviss

Different from surgery, chemical therapy, radio-therapy and target therapy, Chimeric antigen receptor-modified T (CAR-T) cells, a novel adoptive immunotherapy strategy, have been used successfully against both hematological tumors and solid tumors. Although several problems have reduced engineered CAR-T cell therapeutic outcomes in clinical trials for the treatment of thoracic malignancies, includ...

Prostate cancer (PCa) induced death is the predominant cause of cancer-related death among men in 48 countries. After radical treatment, biochemical recurrence has become an important factor for prognosis. The early detection and diagnosis of recurrent lesions are very helpful in guiding treatment and improving the prognosis. PET/CT is a promising method for early detection of lesions in patients ...

An important aspect of studying evolution is to understand how new species are formed and their uniqueness is maintained. Hybridization can lead to the formation of new species through reorganization of the adaptive system and significant changes in phenotype. Interestingly, eight stable strains of 2nNCRC derived from interspecies hybridization have been established in our laboratory. To examine t...

The clinical application process of CAR‐T cell immunotherapy. The clinical process of CAR T is as listed: T lymphocyte collection; CAR T‐cell manufacturing; CAR T‐cell amplification and screening in vitro; CAR‐T cells are infused back into patients; CAR‐T cells are transported to the tumor site and perform their function in the tumor microenvironment. Lung cancer is the highest incidence and mor...

Pancreatic cancer is one of the worst prognoses of all malignant tumors, with an annual incidence near its annual mortality rate. To improve the prognosis of patients with pancreatic cancer, it is essential to diagnose and evaluate pancreatic cancer early. Imaging examinations play an essential role in tumor detection, staging, and surgical resection assessment and can provide reliable evidence fo...

The spermatozoa of triploid gynogenetic crucian carp (Carassius auratus) (3nDTCC) possess a spermatogenesis process with a normal genetic background. However, the genetic materials of these spermatozoa do not completely inherit gynogenetic progeny in general. Understanding the intrinsic mechanism may be helpful for developing breeding strategies of gynogenetic fishes. In this study, the spermatozo...

A new model combing numerical simulation and analytical solution is proposed for U tube ground heat exchanger with varied heat flux boundary. The calculation area is divided into two parts by the boundary of the borehole wall. For the area in the borehole and the surrounding soil area, the calculation method is steady analytical solution and finite volume method respectively. In the borehole, stea...

Introduction Skin cutaneous melanoma (SKCM) is a common skin malignancy worldwide, and its metastasis and mortality rates are high. The molecular characteristics exhibited by tumor–immune interactions have drawn the attention from researchers. Therefore, increased knowledge and new strategies to identify effective immune-related biomarkers may improve the clinical management of SKCM by providing ...

Magnetic resonance diffusion tensor imaging has been developed to a kind of new imaging technology in recent years; through the nerve tissue diffusion properties of water molecules, it can quantitatively reflect the integrity of white matter fiber tracts and various kinds of pathological changes, thus achieving accurate evaluation of spinal cord injuries at the micro level. In this paper, the tech...

Triploid crucian carp (TCC) is obtained by hybridization of female diploid red crucian carp (Carassius auratus red var., RCC) and male allotetraploid hybrids. In this study, high-throughput sequencing was used to conduct the transcriptome analysis of the female hypothalamus of diploid RCC, diploid common carp (Cyprinus carpio L., CC) and TCC. The key functional expression genes of the hypothalamus...