Chan Hyuk Kim

Publications : 43
Aldex : 40
H-index : 20
Citations : 1470

DeepIS: deep learning framework for three-dimensional label-free tracking of immunological synapses

Moosung Lee, YongKeun Park et 7 al.

Jan 1, 2019 in bioRxiv
The immunological synapse (IS) is a cell-cell junction between T cells and professional antigen presenting cells. Since the IS formation is a critical step for the initiation of an antigen-specific immune response, various live-cell imaging techniques, most of which rely on fluorescence microscopy, have been used to study the dynamics of IS. However, the inherent limitations associated with the fl...

Implementation and Characteristic Analysis of DC/DC Voltage Regulator for Operation Efficiency Improvement in PV system

Chan Hyuk Kim, Rho DaeSeok et 4 al.

Jan 1, 2017 in Journal of the Korea Academia Industrial Cooperation Society
Recently, the installation of photovoltaic(PV) systems has been increasing due to the worldwide interest in eco-friendly and abundant solar energy. On the other hand, a PV system has approximately 25% power loss while the energy generated from solar cells is transformed to the power coupling point through a power conversion system (DC/AC). If the output voltage of a string in the PV system is lowe...


biology

Genome editing of immune cells using CRISPR/Cas9

Segi Kim, Chan Hyuk Kim et 3 al.

Jan 1, 2020 in BMB Reports
The ability to read, write, and edit genomic information in living organisms can have a profound impact on research, health, economic, and environmental issues. The CRISPR/Cas system, recently discovered as an adaptive immune system in prokaryotes, has revolutionized the ease and throughput of genome editing in mammalian cells and has proved itself indispensable to the engineering of immune cells ...

genetics

PD-1 and TIGIT downregulation distinctly affect the effector and early memory phenotypes of CD19-targeting CAR T cells.

Young-Ho Lee, Chan Hyuk Kim et 13 al.

Oct 7, 2021 in Molecular therapy
CD19-targeting chimeric antigen receptor (CAR) T cells have become an important therapeutic option for patients with relapsed and refractory B cell malignancies. However, a significant portion of patients still do not benefit from the therapy owing to various resistance mechanisms, including high expression of multiple inhibitory immune checkpoint receptors. Here, we report a lentiviral two-in-one...


biology

Protein conjugation with genetically encoded unnatural amino acids

Chan Hyuk Kim et 3 al.

Jun 1, 2013 in Current Opinion in Chemical Biology

Therapeutic Applications of an Expanded Genetic Code

Sophie B. Sun, Chan Hyuk Kim et 2 al.

Jul 18, 2014 in ChemBioChem


An Immunosuppressive Antibody–Drug Conjugate

Rongsheng E. Wang et 14 al.

Mar 11, 2015 in Journal of the American Chemical Society

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