Carol Brayne

Publications : 1
Aldex : 100
H-index : 0
Citations : 0


Dementia incidence trend over 1992-2014 in the Netherlands: Analysis of primary care data

Emma F. van Bussel et 16 al.

Mar 7, 2017 in PLOS Medicine
Background Recent reports have suggested declining age-specific incidence rates of dementia in high-income countries over time. Improved education and cardiovascular health in early age have been suggested to be bringing about this effect. The aim of this study was to estimate the age-specific dementia incidence trend in primary care records from a large population in the Netherlands. Method an...

Prevalence of Autism Spectrum Conditions in Mainland China

Xiang Sun et 10 al.

Feb 12, 2014 in
The China SCORE study is a prevalence study of Autism Spectrum Conditions (ASC) in 14 regions in mainland China. It will include the following steps: Large population-based screening This study will be conducted in urban areas but not rural areas across mainland China. One city of each region will participate, and in total there will be 14 cities for screening. Within each city, a number of 40 to ...

Lecanemab for Alzheimer's disease.

Sebastian Walsh, Carol Brayne et 4 al.

Dec 19, 2022 in BMJ

Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study.

Valentina Gallo, Paolo Vineis et 40 al.

Mar 11, 2016 in European journal of epidemiology
Previous case-control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were inclu...


The relevance of social and commercial determinants for neurological health.

Sebastian Walsh, Carol Brayne et 2 al.

Dec 1, 2022 in The Lancet. Neurology
A disconnect has developed over the past two decades between neurological and neuroscientific research, which have seen notable innovation and development, and our increasing understanding of the role of social and commercial determinants of health, including the health of the nervous system. Over the next two decades, grounding neurological research in public health and epidemiological principles...

Impact of COVID‐19 policies on perceptions of loneliness in people aged 75 years and over in the cognitive function and aging study (CFAS II)

Connor D. Richardson, Carol Brayne et 6 al.

Nov 12, 2022 in Journal of the American Geriatrics Society
Background The COVID 19 pandemic and associated social distancing measures have profoundly impacted society and social contact patterns, with older people disproportionately affected. Concerns have been raised about a resulting pandemic of loneliness in older people, although the current evidence is mixed. This study provides a unique perspective on the prevalence of loneliness in a population ...


Determinants of cognitive performance and decline in 20 diverse ethno-regional groups: A COSMIC collaboration cohort study.

Darren M Lipnicki et 65 al.

Jul 23, 2019 in PLoS medicine
With no effective treatments for cognitive decline or dementia, improving the evidence base for modifiable risk factors is a research priority. This study investigated associations between risk factors and late-life cognitive decline on a global scale, including comparisons between ethno-regional groups. We harmonized longitudinal data from 20 population-based cohorts from 15 countries over 5 cont...

Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study.

Susanne Röhr et 49 al.

Dec 18, 2020 in Alzheimer's research & therapy
Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer's disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. We combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Ite...

Impact of long-term air pollution exposure on incidence of neurodegenerative diseases: A protocol for a systematic review and exposure-response meta-analysis.

Haneen Khreis, Carol Brayne et 10 al.

Oct 20, 2022 in Environment international
Ambient air pollution is a pervasive and ubiquitous hazard, which has been linked to premature morbidity and a growing number of morbidity endpoints. Air pollution may be linked to neurodegeneration, and via this or other pathways, to neurodegenerative diseases. Emerging evidence suggests that air pollution may contribute to neurodegenerative diseases such as dementia, Parkinson"s Disease (PD), Mu...

The Dementias Platform UK (DPUK) Data Portal.

Sarah Bauermeister et 66 al.

Apr 23, 2020 in European journal of epidemiology
The Dementias Platform UK Data Portal is a data repository facilitating access to data for 3 370 929 individuals in 42 cohorts. The Data Portal is an end-to-end data management solution providing a secure, fully auditable, remote access environment for the analysis of cohort data. All projects utilising the data are by default collaborations with the cohort research teams generating the data. The ...

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