Béatrice Kunz

Publications : 15
Aldex : 20
H-index : 9
Citations : 509


The architecture of the endoplasmic reticulum is regulated by the reversible lipid modification of the shaping protein CLIMP-63

Patrick A. Sandoz et 12 al.

Jan 1, 2018 in bioRxiv
The endoplasmic reticulum (ER) has a complex morphology generated and maintained by membrane-shaping proteins and membrane energy minimization, though not much is known about how it is regulated. The architecture of this intracellular organelle is balanced between large, thin sheets that are densely packed in the perinuclear region and a connected network of branched, elongated tubules that extend...


Identification and dynamics of the DHHC16-DHHC6 palmitoylation cascade

Laurence Abrami et 8 al.

Jan 1, 2017 in bioRxiv
S-Palmitoylation is the only reversible post-translational lipid modification. Knowledge about the DHHC family of palmitoyltransferases is very limited. Here we show that mammalian DHHC6, which modifies key proteins of the endoplasmic reticulum, is controlled by an upstream palmitoyltransferase, DHHC16, revealing the first palmitoylation cascade. Combination of site specific mutagenesis of the thr...

S acylation controls SARS CoV 2 membrane lipid organization and enhances infectivity

Francisco S. Mesquita et 14 al.

Oct 1, 2021 in Developmental Cell
Mesquita et al. report that SARS CoV 2 spike protein undergoes massive lipid modification during viral biogenesis. This controls the membrane, in particular cholesterol, composition of the envelope and enhances infectivity of the viruses.

Palmitoylated calnexin is a key component of the ribosome-translocon complex

Asvin KK Lakkaraju et 8 al.

Feb 7, 2012 in The EMBO Journal

CMG2/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome

Jérôme Bürgi et 11 al.

Jun 12, 2017 in Nature Communications
Loss-of-function mutations in capillary morphogenesis gene 2 (CMG2/ANTXR2), a transmembrane surface protein, cause hyaline fibromatosis syndrome (HFS), a severe genetic disorder that is characterized by large subcutaneous nodules, gingival hypertrophy and severe painful joint contracture. Here we show that CMG2 is an important regulator of collagen VI homoeostasis. CMG2 loss of function promotes a...


Mono-allelic Ly49 NK cell receptor expression

Werner Held et 4 al.

Oct 1, 1999 in Seminars in Immunology

Endocytosis of the Anthrax Toxin Is Mediated by Clathrin, Actin and Unconventional Adaptors

Laurence Abrami et 5 al.

Mar 5, 2010 in PLoS Pathogens
The anthrax toxin is a tripartite toxin, where the two enzymatic subunits require the third subunit, the protective antigen (PA), to interact with cells and be escorted to their cytoplasmic targets. PA binds to cells via one of two receptors, TEM8 and CMG2. Interestingly, the toxin times and triggers its own endocytosis, in particular through the heptamerization of PA. Here we show that PA trigger...

Functional interactions between anthrax toxin receptors and the WNT signalling protein LRP6

Laurence Abrami et 6 al.

Dec 1, 2008 in Cellular Microbiology
To exert its activity, anthrax toxin must be endocytosed and its enzymatic toxic subunits delivered to the cytoplasm. It has been proposed that, in addition to the anthrax toxin receptors (ATRs), lipoprotein‐receptor‐related protein 6 (LRP6), known for its role in Wnt signalling, is also required for toxin endocytosis. These findings have however been challenged. We show that LRP6 can indeed form ...

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