Alviss

Healthcare, Vol. 11, Pages 988: Economic Impacts and Quality of Life for Caregivers of Patients with Retinitis Pigmentosa: A Cross Sectional Japanese Study Healthcare doi: 10.3390/healthcare11070988 Authors: Katsuhiko Watanabe Yoshimune Hiratsuka Shuichi Yamamoto Akira Murakami Retinitis pigmentosa (RP) is the second leading cause of visual impairment in Japan and causes progressive vision loss in...

Gel-forming mucins secreted by conjunctival goblet cells have been implicated in the clearance of allergens, pathogens, and debris. However, their roles remain incompletely understood. Here we show that human and mouse conjunctival goblet cell mucins have Alcian blue-detectable sialic acids, but not sulfates in the steady state. Interestingly, Balb/c mouse strain lacks this sialylation due to a po...

Hereditary retinal degenerations (HRDs) are Mendelian diseases characterized by progressive blindness and caused by ultra-rare mutations. In a genomic screen of 331 unrelated Japanese patients, we identify a disruptive Alu insertion and a nonsense variant (p. Arg1933*) in the ciliary gene RP1, neither of which are rare alleles in Japan. p. Arg1933* is almost polymorphic (frequency = 0.6%, amongst ...

Multidisciplinary efforts to prospectively collect and analyze symptoms of hay fever are limited. We aimed to identify the characteristics of nasal and ocular symptoms of hay fever, using the AllerSearch smartphone application. This mobile health-based prospective observational study using the AllerSearch smartphone application was conducted between February 1, 2018, and May 1, 2020. Individuals w...

Activation of neurotrophic factor signaling is a promising therapy for neurodegeneration. However, the transient nature of ligand-dependent activation limits its effectiveness. In this study, we solved this problem by inventing a system that forces membrane localization of the intracellular domain of Tropomyosin receptor kinase B (iTrkB), which results in constitutive activation without ligands. O...

Highlights •The IL-33-ST2 axis induces axonal elongation in allergic conjunctivitis •A population of memory pathogenic Th2 cells in the conjunctiva express Il1rl1 and Calca •CGRP produced by memory pathogenic Th2 cells drives severe itch in conjunctivitis •CALT structure formation with axonal elongation is observed in human giant papillae

We investigated and characterized the prevalence of dry eye disease (DED) in Parkinson's disease (PD). PubMed and EMBASE databases were searched for relevant studies between January 1, 1979 and March 10, 2022. Quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. Study-specific estimates were combined using the DerSimonian-Laird random-effects model. Prevalence of su...

Highlights •The IL-33-ST2 axis induces axonal elongation in allergic conjunctivitis •A population of memory pathogenic Th2 cells in the conjunctiva express Il1rl1 and Calca •CGRP produced by memory pathogenic Th2 cells drives severe itch in conjunctivitis •CALT structure formation with axonal elongation is observed in human giant papillae

Inherited retinal diseases (IRDs) comprise a phenotypically and genetically heterogeneous group of ocular disorders that cause visual loss via progressive retinal degeneration. Here we report the genetic characterization of 1,210 IRD pedigrees enrolled through the Japan Eye Genetic Consortium and analyzed by whole exome sequencing. The most common phenotype was retinitis pigmentosa (RP, 43%), foll...