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science

Wei Hu, Ping Li, Nianju Zeng, Sheng Tan

Scientific reports
Jan 31, 2023
10.1038/s41598-023-27459-w
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Abstract

Ischemic stroke is highly concerning because it often leads to severe long-term neurological disability. Among clinical trials, ischemic stroke and inflammatory bowel disease interactions have been increasingly reported in recent years. Therefore, using bioinformatics approaches to explore novel protein interactions between them is of interest. We performed this exploratory analysis by using bioinformatics tools such as string to analyze gene data downloaded from NHGRI-GWAS data related to ischemic stroke and inflammatory bowel disease. We constructed a prospective protein interaction network for ischemic stroke and inflammatory bowel disease, identifying cytokine and interleukin-related signaling pathways, Spliceosome, Ubiquitin-Proteasome System (UPS), Thrombus, and Anticoagulation pathways as the crucial biological mechanisms of the network. Furthermore, we also used data-independent acquisition mass spectrometry (DIA-MS) to detect differential protein expression in eight samples, which also suggested that immune system, signal transduction, and hemostasis-related pathways are key signaling pathways. These findings may provide a basis for understanding the interaction between these two states and exploring possible molecular and therapeutic studies in the future.

science

Health risk assessment and metal contamination in fish, water and soil sediments in the East Kolkata Wetlands, India, Ramsar site.

Neeraj Kumar, Nitish Kumar Chandan, Shashi Bhushan, Dilip Kumar Singh, Satish Kumar

Scientific reports
Jan 27, 2023
10.1038/s41598-023-28801-y
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Abstract

East Kolkata Wetlands (EKW) is an important site for fish culture in sewage-fed areas, which are major receivers of pollutants and wastages from Kolkata. EKW is internationally important as the Ramsar site was declared on Aug 2002 with an area of 125 km2. EKW is a natural water body where wastewater-fed natural aquaculture has been practiced for more than 70 years. It is ecologically vulnerable due to the discharge of toxic waste through sewage canals from cities. Assessing the EKW to understand the inflow and load of the toxic metal (s) in fish, water, and sediments samples is essential. The field (samples collection from 13 sites) and lab (determination of toxic level of metals) based research were carried out to assess metal toxicity and health risk assessment in EKW. The levels of eighteen metals (18), namely Chromium, Vanadium, Cobalt, Manganese, Copper, Nickel, Zinc, Silver, Molybdenum, Arsenic, Selenium, Tin, Gallium, Germanium, Strontium, Cadmium, Mercury, and Lead, were determined using Inductively coupled plasma mass spectrometry (ICP-MS) in five fish tissues viz. muscle, liver, kidney, gill and brain, along with the water samples and soil sediments in 13 sampling sites. The bioaccumulation and concentration of metals in fish tissues, soil sediments, and water samples were well within the safe level concerning the recommendation of different national and international agencies except for a few metals in a few sampling sites like Cd, As, and Pb. The geoaccumulation index (Igeo) was also determined in the soil sediments, indicating moderate arsenic, selenium, and mercury contamination in a few sites. The contamination index in water was also determined in 13 sampling sites. The estimated daily intake (EDI), reference dose (RfD), target hazard quotient (THQ), slope factor and cancer risk of Cr, Mn, Co, Ni, Cu, Zn, As, Se, Cd, Pb and Hg from fish muscle were determined. Based on the results of the present investigation, it is concluded that fish consumption in the East Kolkata Wetland (EKW) is safe. The effects of bioaccumulation of metals in muscle tissue were well within the safe level for consumption as recommended by WHO/FAO.

technology

Influence of plutonium content in dissolver solutions derived from irradiated fast reactor fuels on plutonium stripping in multistage countercurrent liquid–liquid extraction with acid split flowsheet

Masaumi Nakahara, Atsuhiro Shibata

Journal of Nuclear Science and Technology
Jan 29, 2023
10.1080/00223131.2022.2162137
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technology

TechCrunch

TechCrunch – Startup and Technology News
Jan 29, 2023
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VC funding to Black web3 founders popped last year, bucking trends
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Abstract

Funding for Black web3 founders has only increased, and the crypto winter proved the most fruitful year.

technology

A Query Optimizer for Range Queries over Multi Attribute Trajectories

Jianqiu Xu Hua Lu Zhifeng Bao

ACM Transactions on Intelligent Systems and Technology
Jan 27, 2023
10.1145/3555811
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Abstract

ACM Transactions on Intelligent Systems and Technology, Volume 14, Issue 1, Page 1 28, February 2023.